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BDNF | Brain-derived neurotrophic factor

350 €

AS13 2691 | clonality: polyclonal | host: Rabbit | reactivity: rat, mouse, human

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AS13 2691

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Background

BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. It promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Binds to NTRK2/TRKB.  It is converted into mature BDNF by plasmin (PLG). Belongs to the NGF-beta family.

Immunogen

A synthetic peptide as a part of human BDNF protein, conjugated to KLH. The BDNF protein sequence is highly conserved amongst primates.

Host Rabbit
Clonality Polyclonal
Clone
Purity Serum
Format Lyophilized
Quantity 100 ĩl
Reconstitution For reconstitution add 100 ĩl of sterile water.
Storage

After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Tested applications Immunohistochemistry (IHC), ELISA, Western blot (WB).
Related products AS16 3242 | BDNF | Brain Derived Neurotrophic Factor (affinity purified)
Additional information
application information
Recommended dilution

A working dilution of 1:1000 to 1:2000 is recommended for the tested applications. Optimal dilutions/concentrations should be determined by the end user.

Expected | apparent MW
Confirmed reactivity

rat, mouse, human

Predicted reactivity
Not reactive in

no confirmed exceptions from predicted reactivity known in the moment

Additional information

to be added when available

Selected references

to be added when available











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