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SCGB2A2 | Mammaglobin-A

371 €

AS03 029  |  clonality: polyclonal  |  host: rabbit  |  reactivity: human

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Item No:
AS03 029

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product information
Background

Mammaglobin is a 93 amino acids peptide belonging to the secretoglobin superfamily. Mammaglobin is expressed by normal breast and skin tissues and is over-expressed in many human breast cancer tumours. In breast tissue, mammaglobin is expressed as a secreted heterodimer together with the other secretoglobin member lipophilin B. Protein synonymes: Mammaglobin-1, Secretoglobin family 2A member 2

Immunogen

KLH-conjugated 16 amino acids-long synthetic peptide derived from C-terminal sequence of human mammaglobin Q13296

Host Rabbit
Clonality Polyclonal
Clone
Purity Affinity purified serum
Format Lyophilized in PBS pH 7.4
Quantity 100 ĩg
Reconstitution For reconstitution add 238 ĩl of sterile water.
Storage

store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.

Tested applications Western blot (WB), immunohistochemistry (IHC), formalin/PFA-fixed paraffin-embedded sections (IHC-P)
Related products

AS03 029S | Mammaglobin blocking peptide

Secondary antibodies

Additional information

no cross-reactivity to lipophilin A, lipophilin B (BU101), lipophilin C (lacryglobin, mammaglobin B), or uteroglobin (Clara cell protein, Clara cell 10 kDa protein) by Western blot analysis of bacterially produced recombinant proteins. Western blot analysis of human breast cancer cells MDA-MB-415 reveals only the mammaglobin band of approximately 15 kDa. Analysis of other cells and tissues might, however, upon prolonged exposure, reveal additional bands at higher molecular weight.

application information
Recommended dilution

1 µg/ml (WB), 1 µg/ml (IHC-P)

Expected | apparent MW

10.5 | 15 kDa

Confirmed reactivity

human

Predicted reactivity

human only

Not reactive in

no confirmed exceptions from predicted reactivity known in the moment

Additional information
Selected references Fischer et al. (2014). Differential expression of secretoglobins in normal ovary and in ovarian carcinoma – Overexpression of mammaglobin-1 is linked to tumor progression. Arch Biochem Biophys. 2014 Mar 3. pii: S0003-9861(14)00077-0. doi: 10.1016/j.abb.2014.02.012.
Sjödin et al (2008). Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation. Anticancer Res. 28:1493-1498.


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