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A1M | Human alpha-1-microglobulin

339 €

AS13 2670 | clonality: polyclonal |  host: hen | reactivity: human

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AS13 2670

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product information
Background

Alpha-1-microglobulin is a 27-kDa glycoprotein with immunosuppressive properties. A gene AMBP in the lipocalin cluster encodes alpha-1-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the alpha-1-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins are secreted to the blood separately. Alpha-1-microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha 1-microglobulin is an immunomodulatory protein with a broad spectrum of possible clinical applications and seems a promising marker for evaluation of tubular function.

Immunogen Full-length human alpha-1-microglobulin (A1M), purified from human urine.
Host Chicken
Clonality Polyclonal
Clone
Purity Total IgY
Format Liquid in PBS
Quantity 100 ĩg
Reconstitution
Storage

store at -20°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.

Tested applications western blot (WB), ELISA (ELISA), radioimmunoassay (RIA)
Related products

AS01 014 | AMBP | Alpha-1-microglobulin

Secondary antibodies

Additional information

IgY concentration is 19,8 mg/ml

application information
Recommended dilution

1: 2000 (WB), 1: 5000 (ELISA)

Expected | apparent MW

27 kDa

Confirmed reactivity

human

Predicted reactivity human, rabbit, cat, rat, Macaca fascicularis, Pan troglodytes, Gorilla, Ailuropoda melanoleuca
Not reactive in

no confirmed exceptions from predicted reactivity known in the moment

Additional information

to be added when available

Selected references Rutardottir et al. (2016). The cysteine 34 residue of A1M/α1-microglobulin is essential for protection of irradiated cell cultures and reduction of carbonyl groups. Free Radic Res. 2013 Jul;47(6-7):541-50. doi: 10.3109/10715762.2013.801555. Epub 2013 May 29.
Olsson MG et al. (2013). The radical-binding lipocalin A1M binds to a Complex I subunit and protects mitochondrial structure and function. Antioxid Redox Signal. 2013 Jun 1;18(16):2017-28.


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