Animal cell antibodies / Human proteins / Immunology

product information

The factor VIII complex, with a molecular weight in excess of 1 million, has 2 components: (1) factor VIII P00451 (molecular weight of 267 kDa) called factor VIII C, when measured by procoagulant activity or factor VIII Ag, when measured immunologically; (2) factor VIII R P04275 (the von Willebrand factor or vWF) has a molecular weight of 225 kDa. Factor VIII, along with calcium and phospholipids, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Domain F5/8 type C 2 Is responsible for  phospholipid binding and essential for factor VIII activity. Defects in F8 are the cause of hemophilia A  (HEMA). HEMA is a common recessive X-linked coagulation disorder.

purified full length native human Coagulation Factor VIII-VWF-F VIII:c complex

store at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.

immunohistochemistry (IHC), ELISA (ELISA)

IMS01-118-307 | anti-Coagulation factor VII

AS00 001 | anti-Coagulation factor VIIa

AS05 058 | anti-Coagulation factor IX

IMS01-137-306 | anti-Coagulation factor XII

IgG concentration is 22.2 µg/µl

application information

1: 200 (IHC)

267 kDa

human

human

no confirmed exceptions from predicted reactivity known in the moment

Immunohistochemistry: antibody was tested on bonin-fixed rat blood vessel.

to be added when available