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LRIG1 | Lig-1

463 €

AS06 156  |  clonality: polyclonal  |  host: hen  |  reactivity: human

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Item No:
AS06 156

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Background

LRIG1 protein Q96JA1 is coded by a gene on a chromosome band 3p14.3, this region is known to be deleted in various human cancers. LRIG1 is considered to be a a tumour suppressor gene in humans. LRIG1 is an integral cell-surface membrane protein that is expressed by specific cells in various human tissues and that its 143-kDa form might be cleaved into 111-kDa and 32-kDa fragments. The LRIG1 protein may inhibit the growth of tumors of glial cells and the down-regulation of the LRIG1 gene may be involved in the development and progression of the tumor.

Immunogen

KLH-conjugated synthetic peptide; the peptide corresponds to part of the cytoplasmic tail (C-terminal part) of the protein

Host Hen
Clonality Polyclonal
Clone
Purity Affinity purified IgY
Format Liquid in PBS pH 8.0, 0.02% sodium azide
Quantity 200 ĩg (1.5 ĩg/ĩl)
Reconstitution
Storage

store at 4°C or at -20°C for long-term storage; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.

Tested applications Western blot (WB)
Related products

AS06 148 | anti-LRIG1 rabbit antibody

Secondary antibodies

Additional information
application information
Recommended dilution

1 µg/ml (WB)

Expected | apparent MW

143 kDa

Confirmed reactivity

human

Predicted reactivity

human

Not reactive in

mouse

Additional information

LRIG1 protein is migrating in denaturing polyacrylamide gel electrophoresis under reducing conditions as two species with apparent molecular weights of 143kDa and 134 kDa, and as two fragments corresponding to an N-terminal 111-kDa species and a C terminal 32-kDa species. Under non-reducing conditions,both apparent monomers and apparent higher molecular weight complexes were evident.

Selected references

to be added when available



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