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LRIG1 | Lig-1 (40 ĩg, ALP-conjugated)

406 €

AS06 148-ALP  |  clonality: polyclonal  |  host: rabbit  |  reactivity: human, mice

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AS06 148-ALP

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product information
Background

LRIG1 protein Q96JA1 is coded by a gene on a chromosome band 3p14.3, this region is known to be deleted in various human cancers. LRIG1 is considered to be a a tumour suppressor gene in humans. LRIG1 is an integral cell-surface membrane protein that is expressed by specific cells in various human tissues and that its 143-kDa form might be cleaved into 111-kDa and 32-kDa fragments. The LRIG1 protein may inhibit the growth of tumors of glial cells and the down-regulation of the LRIG1 gene may be involved in the development and progression of the tumor.

Immunogen

KLH-conjugated synthetic peptide; the peptide corresponds to part of the cytoplasmic tail (C-terminal part) of the protein, not the ectodomain

Host Rabbit
Clonality Polyclonal
Clone
Purity Affinity purified IgG
Format Liquid in PBS pH 7.4, conjugated to ALP
Quantity 40 µg
Reconstitution
Storage

Store at +4°C for 12-18 months. A preservative may be added for long time storage up to 2 years.

Tested applications Western blot (WB), immunolocalization (IL)
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Secondary antibodies

Additional information

Peptide used to elicit Lrig1 antibody is not conserved in Lrig3 protein.

application information
Recommended dilution

1 µg/ml (WB), 1: 100 (IL)

Expected | apparent MW

143 kDa

Confirmed reactivity human, mice
Predicted reactivity

human

Not reactive in

no confirmed exceptions from predicted reactivity known in the moment

Additional information

immunoblotting demonstrated LRIG1 protein in tissue lysates from normal human prostate, mammary epithelial cells, ileum, stomach, lung, and cerebral cortex

Selected references


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