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THP | Allopregnanolone steroid standard

238 €

AS04 041S  |  GMP manufactured steroid standard

PRODUCT INFORMATION IN PDF

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5 st
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Item No:
AS04 041S

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product information
Background

Allopregnanolone, (3alpha-hydroxy-20-oxo-5alphapregnan-11alpha-yl-carboxymethylether), also known as 3alpha,5alpha-tetrahydroprogesterone or THP, a neuroactive steroid secreted by the mammalian ovary, exerts its anesthetic, anxiolytic, and sedative/hypnotic effects through potentiation of GABA A receptors. It is produced in the human corpus luteum and their release is stimulated by trophic hormone.

Immunogen

produced by Umecrine AB

Host
Clonality
Clone
Purity
Format Lyophilized
Quantity 10 mg
Reconstitution
Storage

store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.

Tested applications radioimmunoassay (RIA)
Related products

AS04 041 | anti-allopregnanolone antibody

Additional information

allopregnanolone standard is made under GMP conditions and thus has the purity standards required for human usage in clinical trials

application information
Recommended dilution
Expected | apparent MW
Confirmed reactivity
Predicted reactivity
Not reactive in

no confirmed exceptions from predicted reactivity known in the moment

Additional information Prepare a stock solution with the concentration of 1 mg/ml. Dilute further to desired concentration. 99.5 % Ethanol can be used as a diluent. If necessary, ethanol can be evaporated before adding water based solutions.
Selected references Lee at al. (2014). Progesterone and allopregnanolone improve stroke outcome in male mice via distinct mechanisms but neither promotes neurogenesis. J of Neurochemistry, DOI: 10.1111/jnc.12990.


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