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THP | Allopregnanolone steroid standard

238 €

AS04 041S  |  GMP manufactured steroid standard

PRODUCT INFORMATION IN PDF

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5 st
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Item No:
AS04 041S

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product information
Background

Allopregnanolone, (3alpha-hydroxy-20-oxo-5alphapregnan-11alpha-yl-carboxymethylether), also known as 3alpha,5alpha-tetrahydroprogesterone or THP, a neuroactive steroid secreted by the mammalian ovary, exerts its anesthetic, anxiolytic, and sedative/hypnotic effects through potentiation of GABA A receptors. It is produced in the human corpus luteum and their release is stimulated by trophic hormone.

Host
Clonality
Clone
Purity
Format Lyophilized
Quantity 10 mg
Reconstitution
Storage

Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.

Protect from light.

Can be stored for 1 month at 4°C in a sealed tube or flask.

Tested applications Radioimmunoassay (RIA)
Related products

AS04 041 | anti-allopregnanolone antibody

Additional information

Allopregnanolone standard is made under GMP conditions and thus has the purity standards required for human usage in clinical trials. Produced by Umecrine AB.

application information
Recommended dilution
Expected | apparent MW
Confirmed reactivity
Predicted reactivity
Not reactive in
Additional information The lyophilized powder of this standard is not soluble in water.

Standard dissolving instruction:
  • Use ethanol (99.5 %) or methanol to prepare a concentrated (stock) solution of THP standard. This solution can be stored for longer time in a sealed tube.
  • Working solution can be used daily but needs to be changed after one month.
  • Working solution is used to prepare standard points 0-200 pg. It needs to be dried under nitrogen before it is diluted in water based soltion, otherwise the steroid will oxidase.
  • Following dyring, water based solution can be added to this standard.
Selected references Lee at al. (2014). Progesterone and allopregnanolone improve stroke outcome in male mice via distinct mechanisms but neither promotes neurogenesis. J of Neurochemistry, DOI: 10.1111/jnc.12990.


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