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THP | Allopregnanolone

371 €

AS04 041  |  clonality: polyclonal  |  host: hen  |  reactivity: allopregnanolone

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2 st
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AS04 041

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product information
Background

Allopregnanolone, (3alpha-hydroxy-5alpha-pregnan-20-ol), also known as 3alpha,5alpha-tetrahydroprogesterone or THP, is a neuroactive steroid secreted by the mammalian ovary and adrenal. It exerts its anesthetic, anxiolytic, and sedative/hypnotic effects through potentiation of GABA A receptors and its release is stimulated by trophic hormones in relation to stress and reproductive hormone secretion.

Immunogen

BSA conjugated-allopregnanolone

Host Chicken
Clonality Polyclonal
Clone
Purity Total IgY
Format Liquid in PBS pH 8.0, 0.02% sodium azide
Quantity 100 µl
Reconstitution
Storage

store at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.

Tested applications radioimmunoassay (RIA)
Related products

AS04 041S | Allopregnanolone steroid standard

Secondary antibodies

Additional information

100 µl will be enough to perform 60 double samples, generating standard curve and blank

Waters column Symmetry C18 3.5um 4.6 x 75mm with 3.9 x 20mm as guard column has been used

application information
Recommended dilution

1: 1000 (RIA)

Expected | apparent MW
Confirmed reactivity allopregnanolone
Predicted reactivity

not applicable

Not reactive in

no confirmed exceptions from predicted reactivity known in the moment

Additional information

detailed method description is available here.
For bulk wuantity order - please inquire.

Selected references Cumberland et al. (2017). Effects of combined IUGR and prenatal stress on the development of the hippocampus in a fetal guinea pig model. J Dev Orig Health Dis. 2017 May 15:1-13. doi: 10.1017/S2040174417000307.
Bennett et al. (2015). Prenatal Stress Alters Hippocampal Neuroglia and Increases Anxiety in Childhood. Dev Neurosci. 2015 Aug 13.
Rault et al. (2015). Allopregnanolone and social stress: regulation of the stress response in early pregnancy in pigs. Stress. 2015 Jun 11:1-9.
Boher et al. (2014). The effects of betamethasone on allopregnanolone concentrations and brain development in preterm fetal sheep. J Exp Bot. 2013 Aug;64(11):3225-36. doi: 10.1093/jxb/ert163.


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