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TrkA | Tyrosine Kinase Receptor A

350 €

AS13 2698 | clonality: polyclonal | host: rabbit | reactivity: human, rat, mouse

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AS13 2698

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Background

TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating.

Immunogen

Extracellular domain of glycosylated human TrkA protein produced in CHO cells was used as the immunogen.

Host Rabbit
Clonality Polyclonal
Clone
Purity Serum
Format Lyophilized
Quantity 100 ĩl
Reconstitution For reconstitution please add 100 ĩl of sterile water
Storage

After reconstitution keep aliquots at -20ºC for a higher stability, and at  4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Tested applications Immunohistochemistry (IHC), 1-site ELISA
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Additional information
application information
Recommended dilution

1-site ELISA (1:5000 dilution). A dilution of 1:1000 is recommended for IHC. Optimal dilutions/concentrations should be determined by the end user.

Expected | apparent MW
Confirmed reactivity

human, rat, mouse

Predicted reactivity

not yet tested in other species

Not reactive in
Additional information
Selected references

to be added when available


Application example



Immunohistochemical staining of Tyrosine Kinase Receptor A (TrkA) in rat spinal cord (free floating cryostat section) using rabbit antibody (AS13 2698) at a dilution of 1 in 2000. Courtesy of Professor Xin Fu Zhou, The Flinders University of South Australia.








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