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TrkB | Tyrosine Kinase Receptor B

350 €

AS13 2697 | clonality: polyclonal | host: rabbit | reactivity: rat, mouse

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AS13 2697

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product information
Background

TrkB is a member of the neurotrophic tyrosine receptor kinase family. It is a membrane-bound receptor and upon neurotrophin binding, it phosphorylates itself as well as MAPK pathways members. TrkB is the receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). It is Involved in the development and/or maintenance of the nervous system. 

Immunogen

Extracellular domain of glycosylated mouse TrkB protein produced in CHO cells was used as the immunogen. As shown for similar antisera, it is anticipated that this antibody will block the TrkB receptor binding of corresponding neurotrophin ligand.

Host Rabbit
Clonality Polyclonal
Clone
Purity Serum
Format Lyophilized
Quantity 100 ĩl
Reconstitution For reconstitution please add 100 ĩl of sterile water
Storage

After reconstitution keep aliquots at -20ºC for a higher stability, and at  4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Tested applications Immunohistochemistry (IHC), 1-site ELISA
Related products
Additional information
application information
Recommended dilution

1-site ELISA (1:10000 dilution). A dilution of 1:1000 to 1:3000 is recommended for IHC. Optimal dilutions/concentrations should be determined by the end user.

Expected | apparent MW
Confirmed reactivity

rat, mouse

Predicted reactivity

not yet tested in other species

Not reactive in
Additional information

to be added when available

Selected references

to be added when available


Application example





Immunohistochemical staining of Tyrosine Kinase Receptor B (TrkB) in rat ventral horn (free floating cryostat section) using rabbit antibody (AS13 2697) at a dilution of 1 in 3000. Courtesy of Professor Xin Fu Zhou, The Flinders University of South Australia






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