ASyM-biotinylated | Mouse anti-human alpha synuclein N-terminal
AS13 2719B | Clonality: monoclonal | Host: Mouse | Reactivity: Human
- Product Info
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Immunogen: synthetic peptide derived from human alpha-synuclein N-terminal Met1-Val15
Sub class: IgG2a Host: Mouse Clonality: Monoclonal Purity: Immunoglobulin affinity purified in PBS pH 7.4. Format: Lyophilized Quantity: 50 µg Reconstitution: For reconstitution add 50 µl of sterile water Storage: For short time storage add sodium azide and store at +4°C. For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube. Tested applications: ELISA (ELISA) Recommended dilution: 2-4 ug/ml (ELISA capture) Expected | apparent MW: 14 kDa
- Reactivity
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Confirmed reactivity: Human Not reactive in: No confirmed exceptions from predicted reactivity are currently known - Additional Information
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Additional information: This antibody is biotinylated.
Cross reactivity of this antibody to synuclein beta was not determined. - Background
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Background: Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed.
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