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F8 | Coagulation factor VIII

304 €

IMS01-015-308  |  clonality: polyclonal  |  host: hen  |  reactivity: human

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IMS01-015-308

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product information
Background

The factor VIII complex, with a molecular weight in excess of 1 million, has 2 components: (1) factor VIII P00451 (molecular weight of 267 kDa) called factor VIII C, when measured by procoagulant activity or factor VIII Ag, when measured immunologically; (2) factor VIII R P04275 (the von Willebrand factor or vWF) has a molecular weight of 225 kDa. Factor VIII, along with calcium and phospholipids, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Domain F5/8 type C 2 Is responsible for  phospholipid binding and essential for factor VIII activity. Defects in F8 are the cause of hemophilia A  (HEMA). HEMA is a common recessive X-linked coagulation disorder.

Immunogen

purified full length native human Coagulation Factor VIII-VWF-F VIII:c complex

Host Hen
Clonality Polyclonal
Clone
Purity Total IgY fraction
Format Liquid in 0.9% NaCl, 0.1% sodium azide
Quantity 100 ĩl (20 mg/ml)
Reconstitution
Storage

store at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.

Tested applications immunohistochemistry (IHC), ELISA (ELISA)
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Secondary antibodies

Additional information

IgG concentration is 22.2 µg/µl

application information
Recommended dilution

1: 200 (IHC)

Expected | apparent MW

267 kDa

Confirmed reactivity

human

Predicted reactivity

human

Not reactive in

no confirmed exceptions from predicted reactivity known in the moment

Additional information

Immunohistochemistry: antibody was tested on bonin-fixed rat blood vessel.

Selected references

to be added when available



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