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Mouse IgG anti-transthyretin 39-44, amyloid specific

325 €

AS16 3112   | clonality: monoclonal  |  host: mouse  |  reactivity: human

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AS16 3112

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Background

Transthyretin is a carrier protein in plasma of the thyroid hormone. This protein forms a complex with retinol-binding protein and it has the capability of forming amyloid fibrils. 25% of individuals older than 80 years are affected by senile systemic amyloidosis and most cases of TTR-associated amyloidosis are linked to point mutations. A substitution of valine for methionine at position 30 of the 127-aa-long polypeptide is one of the most common forms, leading to many symptoms in the peripheral nervous system, a familial amyloidosis with polyneuropathy.

Immunogen

synthetic peptide chosen from human transthyretin 39-44 protein

Host Mouse
Clonality Monoclonal
Clone IgG
Purity Affinity purified
Format Lyophilized
Quantity 100 ĩg
Reconstitution For reconstitution add 100 ĩl of sterile water.
Storage

For short time storage please add sodium azide and srote at +4°C.
For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.

Tested applications ELISA (ELISA), Western Blot (WB), immunohistochemistry (IHC)
Related products

AS16 3113 | Mouse IgG anti-transthyretin 56-61 (amyloid specific)

Additional information
application information
Recommended dilution

5 μg/ml (ELISA), 2 µg/ml (WB), 5 µg/ml (IHC)

Expected | apparent MW
Confirmed reactivity human
Predicted reactivity n.a.
Not reactive in

no confirmed exceptions from predicted reactivity are currently known

Additional information

to be added when available

Selected references Goldsteins et al. (1999). Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6): 3108–3113

application examples




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