Animal cell antibodies / Human proteins / Cancer

product information

Mammaglobin is a 93 amino acids peptide belonging to the secretoglobin superfamily. Mammaglobin is expressed by normal breast and skin tissues and is over-expressed in many human breast cancer tumours. In breast tissue, mammaglobin is expressed as a secreted heterodimer together with the other secretoglobin member lipophilin B. Protein synonymes: Mammaglobin-1, Secretoglobin family 2A member 2

KLH-conjugated 16 amino acids-long synthetic peptide derived from C-terminal sequence of human mammaglobin Q13296

store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.

Western blot (WB), immunohistochemistry (IHC), formalin/PFA-fixed paraffin-embedded sections (IHC-P)

AS03 029S | Mammaglobin blocking peptide

no cross-reactivity to lipophilin A, lipophilin B (BU101), lipophilin C (lacryglobin, mammaglobin B), or uteroglobin (Clara cell protein, Clara cell 10 kDa protein) by Western blot analysis of bacterially produced recombinant proteins. Western blot analysis of human breast cancer cells MDA-MB-415 reveals only the mammaglobin band of approximately 15 kDa. Analysis of other cells and tissues might, however, upon prolonged exposure, reveal additional bands at higher molecular weight.

application information

1 µg/ml (WB), 1 µg/ml (IHC-P)

10.5 | 15 kDa

human

human only

no confirmed exceptions from predicted reactivity known in the moment

to be added when available

Sjödin et al. (2003). Mammaglobin in normal human swet glands and human swet gland tumors. J.Invest Dermatol. 121:428-429; Sjödin et al (2008). Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation. Anticancer Res. 28:1493-1498.