Fibrinogen | unconjugated antibody

Name: Fibrinogen | unconjugated antibody
SKU: AS10 1337
Price: 306 EUR
Availability: InStock

AS10 1337 | Clonality: Polyclonal | Host: Goat | Reactivity: Human fibrinogen

Fibrinogen | unconjugated antibody in the group Antibodies Human Cell Biology / Cardiovascular at Agrisera AB (Antibodies for research) (AS10 1337)

Product Information

Immunogen human fibrinogen CAA50740

Host Goat

Clonality Polyclonal

Purity Immunogen affinity purified using solid phase human Fibrinogen.

Format Liquid

Quantity 1 mg

Storage Store at 2-8°C.

Tested applications Immunoassays

Recommended dilution The optimal working dilution should be determined by the investigator

Expected | apparent MW

24 kDa

Reactivity

Confirmed reactivity Human fibrinogen

Predicted reactivity Chicken, Mouse

Not reactive in No confirmed exceptions from predicted reactivity are currently known

Application examples

Additional information

Affinity purified using solid phase human fibrinogen.

Antibody is supplied in 10 mM sodium phosphate, 0.15 M sodium chloride, pH 7.2. Contains 0.05% (w/v) sodium azide as preservative. Antibody purity is > 95% based on SDS-PAGE.

Background

Background Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000; Rapold et al. 1989).

Product citations

background:	Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000; Rapold et al. 1989).
calculated \| apparent molecular mass [kDa]:	24 kDa
Clonality:	Polyclonal
Format:	Liquid
Host:	Goat
immunogen:	human fibrinogen CAA50740
Purity:	Immunogen affinity purified using solid phase human Fibrinogen.
Quantity:	1 mg
recommended dilution:	The optimal working dilution should be determined by the investigator
storage:	Store at 2-8°C.
tested applications:	Immunoassays
additional information (application):	Affinity purified using solid phase human fibrinogen. Antibody is supplied in 10 mM sodium phosphate, 0.15 M sodium chloride, pH 7.2. Contains 0.05% (w/v) sodium azide as preservative. Antibody purity is > 95% based on SDS-PAGE.
Confirmed reactivity:	Human fibrinogen
predicted reactivity:	Chicken, Mouse
not reactive in:	No confirmed exceptions from predicted reactivity are currently known