Fibrinogen | unconjugated antibody
AS10 1337 | Clonality: Polyclonal | Host: Goat | Reactivity: Human fibrinogen
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Immunogen human fibrinogen CAA50740
Purity Immunogen affinity purified using solid phase human Fibrinogen.
Quantity 1 mg
Storage Store at 2-8°C.
Tested applications Immunoassays
Recommended dilution The optimal working dilution should be determined by the investigator
Expected | apparent MW
Confirmed reactivity Human fibrinogen
Predicted reactivity Chicken, Mouse
Not reactive in No confirmed exceptions from predicted reactivity are currently known
Affinity purified using solid phase human fibrinogen.
Antibody is supplied in 10 mM sodium phosphate, 0.15 M sodium chloride, pH 7.2. Contains 0.05% (w/v) sodium azide as preservative. Antibody purity is > 95% based on SDS-PAGE.
Background Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000; Rapold et al. 1989).
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