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AMBP | Alpha-1-microglobulin

AS01 014  |  Clonality: Polyclonal  |  Host: Rabbit  |  Reactivity: Rat

AMBP | Alpha-1-microglobulin in the group Antibodies Human Research / Other proteins at Agrisera AB (Antibodies for research) (AS01 014)



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Product Information

Immunogen

rat alpha-1-microglobulin, full length, recombinant protein, overexpressed in baculovirus-infected insect cells with N-terminal His-tag

Host Rabbit
Clonality Polyclonal
Purity Serum with 0.04% sodium azide.
Format Lyophilized
Quantity 200 ĩl
Reconstitution For reconstitution add 200 ĩl of sterile water
Storage Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Tested applications Immunocytochemistry (ICC), Radioimmunoassay (RIA), Western blot (WB)
Recommended dilution 1 : 5000 (ELISA), 1 : 200 (IHC), 1 : 6000 (RIA), 1 : 2000 (WB)
Expected | apparent MW

27 kDa

Reactivity

Confirmed reactivity Rat
Predicted reactivity Mouse
Not reactive in No confirmed exceptions from predicted reactivity are currently known

Application examples

Additional information

Related products

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AS01 013 | Anti-alpha-1-microglobulin (abcam BN11.10), mouse monoclonal antibody

AS13 2670 | Anti-A1M | human alpha-1-microglobulin, chicken antibody

AS10 1354 | Anti-B2M | beta-2-microglobulin, goat antibody

Background

Background

Alpha-1-microglobulin is a 27-kDa glycoprotein with immunosuppressive properties. A gene AMBP in the lipocalin cluster encodes alpha-1-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the alpha-1-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins are secreted to the blood separately. Alpha-1-microglobulin is found in blood and in connective tissue in most organs. It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha 1-microglobulin is an immunomodulatory protein with a broad spectrum of possible clinical applications and seems a promising marker for evaluation of tubular function.

Product citations

Selected references Wen et al. (2017). MicroRNA-148b regulates megalin expression and is associated with receptor downregulation in mice with unilateral ureteral obstruction. Am J Physiol Renal Physiol. 2017 Mar 22:ajprenal.00585.2016. doi: 10.1152/ajprenal.00585.2016.
Ostendorf et al. (2006) Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis. J Am Soc Nephrol, 17:1054-62.
Sanchez et al. (2002) Expression of the AMBP gene transcript and its two protein products, alpha(1)-microglobulin and bikunin, in mouse embryogenesis. Mech Dev, 117:293-8.

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