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THDOC | Tetrahydrodeoxycorticosterone

AS06 192  |  Clonality: Polyclonal  |  Host: Hen  |  Reactivity: THDOC

THDOC | Tetrahydrodeoxycorticosterone in the group Human/Animal Antibodies / Neurosteroids/Neurobiology at Agrisera AB (Antibodies for research) (AS06 192)

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Product Information

Immunogen

BSA-coupled THDOC

Host Chicken
Clonality Polyclonal
Purity Total IgY
Format Liquid in PBS pH 8.0, 0.02% sodium azide
Quantity 100 ĩl
Storage Store at 4°C or at -20°C for long-term storage; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
Tested applications Radioimmunoassay (RIA)
Recommended dilution 1 : 1000 (RIA)

Reactivity

Confirmed reactivity THDOC

Application examples

Additional information

Method description available under "more information".

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Background

Background

TetraHydroDesOxyCorticosterone (THDOC) is a stress related neuroactive steroid. THDOC is a metabolite of desoxycoritcosterone (DOC) and progesterone and DOC is a steroid in the synthesis pathway to aldosterone. THDOC is produced by the adrenal in parallel with cortisol at stress and is regulated by  ACTH. THDOC is a potent positive modulator of the GABA A receptor. THDOC passes the blood-brain barrier and can be found in the brain after stress in nanomolar concentrations.

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Selected references

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