ASY1 | Asynaptic phenotype protein 1
AS08 323 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Barchypodium distachyon, Triticum aestivum
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Recombinant, full length, ASY1 protein produced in E.coli prepared from the sequence of Triticum aestivum ASY1 A7TVU8
Pairing and synapsis of homologous chromosomes is required for normal chromosome segregation and the exchange of genetic material via recombination during meiosis. Synapsis is complete at pachytene following the formation of a tri-partite proteinaceous structure known as the synaptonemal complex (SC). In yeast, HOP1 is essential for formation of the SC, and localises along chromosome axes during prophase I. Homologues in Arabidopsis (AtASY1), Brassica (BoASY1) and rice (OsPAIR2) have been isolated through analysis of mutants that display decreased fertility due to severely reduced synapsis of homologous chromosomes. Analysis of these genes has indicated that they play a similar role to HOP1 in pairing and formation of the SC through localisation to axial/lateral elements of the SC.