BDNF | Brain-derived neurotrophic factor

AS13 2691 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Rat, Mouse, Human

BDNF | Brain-derived neurotrophic factor in the group Antibodies Human Cell Biology / Neuroscience / Neurodegenerative diseases / Parkinson's disease at Agrisera AB (Antibodies for research) (AS13 2691)


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Product Information


KLH-conjugated synthetic peptide HSDPARRGEL. The BDNF protein sequence is highly conserved amongst primates.

Host Rabbit
Clonality Polyclonal
Purity Serum
Format Lyophilized
Quantity 100 ĩl
Reconstitution For reconstitution add 100 ĩl of sterile water
Storage After reconstitution keep aliquots at -20šC for a higher stability. and at 4šC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Tested applications ELISA (ELISA), Immunohistochemistry (IHC), Western blot (WB)
Recommended dilution 1 : 1000-1 : 2000 (ELISA), (IHC), (WB)


Confirmed reactivity Human, Mouse, Rat
Not reactive in No confirmed exceptions from predicted reactivity are currently known

Application examples

Application examples

Additional information

This antibody detects multiple BDNF isoforms (14 kDa mature BDNF, 18 kDa isoform, 28 kDa BDNF dimer/truncated BDNF, 32 kDa proBDNF monomer), depending upon sample type (human serum, cell lysate, tissue homogenate.

This antibody is also recognizing BDNF in non denaturing conditions.

Cross reaction with mouse NGF recombinant human NT3 and NT4/5 is lower than 0.1 % as confirmed by dot blot analysis.

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Related products AS16 3242 | Anti-BDNF | Brain Derived Neurotrophic Factor (affinity purified antibodies)



BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. It promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Binds to NTRK2/TRKB.  It is converted into mature BDNF by plasmin (PLG). Belongs to the NGF-beta family.

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