BDNF | Brain-derived neurotrophic factor
AS13 2691 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Rat, Mouse, Human
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KLH-conjugated synthetic peptide HSDPARRGEL. The BDNF protein sequence is highly conserved amongst primates.
After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
This antibody is also recognizing BDNF in non denaturing conditions.
Cross reaction with mouse NGF recombinant human NT3 and NT4/5 is lower than 0.1 % as confirmed by dot blot analysis.
BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. It promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Binds to NTRK2/TRKB. It is converted into mature BDNF by plasmin (PLG). Belongs to the NGF-beta family.