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Capsaicin receptor
AS13 2701 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Human, Mouse, Rat
- Product Info
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Immunogen: A synthetic peptide of human capsaicin receptor protein conjugated to KLH has been used as the immunogen, Host: Rabbit Clonality: Polyclonal Purity: Serum Format: Lyophilized Quantity: 100 µl Reconstitution: For reconstitution add 100 µl of sterile water Storage: After reconstitution keep aliquots at -20ºC for a higher stability. and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles. Tested applications: Immunohistochemistry (IHC) Recommended dilution: 1 : 1000-1 : 2000 (IHC) - Reactivity
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Confirmed reactivity: Human, Mouse, Rat - Application Examples
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Application example 
Immunohistochemical staining of rat spinal cord using rabbit antibody to human capsaicin receptor, catalog number AS13 2701.
Immunohistochemistry showing capsaicin receptor (TRPV1, red) and neurofilament-heavy chain (NFL, green) reactivity in nociceptive sensory neurons derived from hESC. Fixation: 4% PFA 10 min. on ice. Blocking: 10% FCS/PBST for 1h at RT Primary: 1:100 in blocking solution for 1h at RT Secondary: 1:500 in blocking solution for 1h at RT, secondary antibodies: donkey anti-mouse 488 and donkey anti-rabbit 568.
Courtesy of Dr. Iwan Jones, Umeå University, Sweden - Background
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Background: Capsaicin receptor is predominantly expressed in trigeminal and dorsal root sensory ganglia. Isoform 1 and isoform 3 are also expressed in brain and peripheral blood mononuclear cells. Synonyms: The transient receptor potential cation channel subfamily V member 1 (TrpV1) and the vanilloid receptor 1
- Product Citations
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Selected references: Jones et al. (2018). Development and validation of an in vitro model system to study peripheral sensory neuron development and injury. Sci Rep. 2018 Oct 29;8(1):15961. doi: 10.1038/s41598-018-34280-3. - Reviews:
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