CASP3 | Caspase-3 (clone AM 1 4)
AS16 4001 | Clonality: Monoclonal | Host: Mouse | Reactivity: Human
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Immunogen Recombinant human Caspase-3 protein. UniProt: P42574
Purity Protein A/G purified
Quantity 100 µg
Storage Store at -20°C.
Tested applications Western blot (WB)
Recommended dilution The optimal working dilution should be determined by the investigator.
Confirmed reactivity Human
Not reactive in No confirmed exceptions from predicted reactivity are currently known.
Additional information Provided in phosphate buffered saline, contains 0.08% sodium azide.
Background Caspase-3 is involved in the activation cascade of caspases, this cascade is responsible for apoptosis execution. It cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Caspase-3 belongs to the group of effector caspases that are involved in the cleavage of multiple substrates including the cytokeratins, PARP, alpha fodrin, NuMA and others.