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CASP3 | Caspase-3 (clone AM 1 4)

AS16 4001 | Clonality: Monoclonal | Host: Mouse | Reactivity: Human

CASP3 | Caspase-3 (clone AM 1 4) in the group Antibodies for Human/Animal  / Neurosteroids/Neurobiology at Agrisera AB (Antibodies for research) (AS16 4001)

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Product Information

Immunogen Recombinant human Caspase-3 protein. UniProt: P42574
Host Mouse
Clonality Monoclonal
Subclass/isotype IgG
Purity Protein A/G purified
Format Liquid
Quantity 100 µg
Storage Store at -20°C.
Tested applications Western blot (WB)
Recommended dilution The optimal working dilution should be determined by the investigator.

Reactivity

Confirmed reactivity Human
Not reactive in No confirmed exceptions from predicted reactivity are currently known.

Application examples

Additional information

Additional information Provided in phosphate buffered saline, contains 0.08% sodium azide.

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Background

Background Caspase-3 is involved in the activation cascade of caspases, this cascade is responsible for apoptosis execution. It cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Caspase-3 belongs to the group of effector caspases that are involved in the cleavage of multiple substrates including the cytokeratins, PARP, alpha fodrin, NuMA and others.

Product citations

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