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F12 | Coagulation factor XII

IMS01-137-306  |  Clonality: Polyclonal  |  Host: hen  |  rectivity: Human

F12 | Coagulation factor XII  in the group Antibodies for Human/Animal  / Human Proteins / Immunology at Agrisera AB (Antibodies for research) (IMS01-137-306)

DATA SHEET IN PDF

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336
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Product name, number (Agrisera, Sweden)

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Product Information

Immunogen

purified full length native protein UnniProt:P00748

Host Chicken
Clonality Polyclonal
Purity Total IgY fraction
Format Liquid in 0.9% NaCl, 0.1% sodium azide
Quantity 100 µl (15.1 mg/ml)
Storage Store at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
Tested applications Total, purified IgY
Recommended dilution

1: 10 000 (ELISA)

Expected | apparent MW

67 kDa

Reactivity

Confirmed reactivity Human
Predicted reactivity Human
Not reactive in No confirmed exceptions from predicted reactivity are currently known.

Application examples

Additional information

Detects human coagulation factor XII and XIIa.

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Secondary antibodies

Background

Background

Coagulation factor XII circulates in blood as a zymogen. This single chain zymogen is converted to a two chain serine protease with an heavy chain (alpha factor XIIa) and a light chain. The heavy chain contains two fibronectin type domains, two epidermal growth factor (EGF) like domains, a kringle domain and a proline rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta factor XIIa light chain and the alpha factor XIIa light chain becomes beta factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha factor XIIa and then to beta factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in Factor XII gene do not cause any apparent clinical symptoms and the sole effect is that whole blood clotting time is prolonged.

Product citations

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