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F8 | Coagulation factor VIII

IMS01-015-308  |  Clonality: Polyclonal  |  Host: Hen  |  Reactivity: Human

F8 | Coagulation factor VIII in the group Antibodies for Human/Animal  / Human Proteins / Immunology at Agrisera AB (Antibodies for research) (IMS01-015-308)

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Product Information

Immunogen

purified full length native human Coagulation Factor VIII-VWF-F VIII:c complex

Host Chicken
Clonality Polyclonal
Purity Total IgY fraction
Format Liquid in 0.9% NaCl, 0.1% sodium azide
Quantity 100 µl (20 mg/ml)
Storage Store at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
Tested applications Total, purified IgY
Recommended dilution 1 : 200 (IHC)
Expected | apparent MW

267 kDa

Reactivity

Confirmed reactivity Human
Predicted reactivity Human
Not reactive in No confirmed exceptions from predicted reactivity are currently known.

Application examples

Additional information

Additional information

IgG concentration is 22.2 µg/µl

Immunohistochemistry: antibody was tested on bonin-fixed rat blood vessel.

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Secondary antibodies

Background

Background

The factor VIII complex, with a molecular weight in excess of 1 million, has 2 components: (1) factor VIII P00451 (molecular weight of 267 kDa) called factor VIII C, when measured by procoagulant activity or factor VIII Ag, when measured immunologically; (2) factor VIII R P04275 (the von Willebrand factor or vWF) has a molecular weight of 225 kDa. Factor VIII, along with calcium and phospholipids, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Domain F5/8 type C 2 Is responsible for  phospholipid binding and essential for factor VIII activity. Defects in F8 are the cause of hemophilia A  (HEMA). HEMA is a common recessive X-linked coagulation disorder.

Product citations

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