Fibrinogen
IMS02-038-341 | Clonality: Polyclonal | Host: Hen | Reactivity: Human
- Product Info
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Immunogen: Purified, full length native fibrinogen Q9UE34
Host: Chicken Clonality: Polyclonal Purity: Immunogen affinity purified IgY in 0.15M sodium chloride, 0.02M sodium phosphate, 0.1% sodium azide., pH 7.2. Format: Liquid Quantity: 100 µg Storage: Store at 4°C; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube. Recommended dilution: 1 : 5000 (WB) Expected | apparent MW: 75 kDa
- Reactivity
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Confirmed reactivity: Human Predicted reactivity: Bovine, Mouse, Porcine, Rabbit, Rat Not reactive in: No confirmed exceptions from predicted reactivity are currently known - Additional Information
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Additional information (application): Only one precipitation arc in immunodiffusion and immunoelectrophoresis against normal human plasma or human fibrinogen - Background
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Background: Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000; Rapold et al. 1989).
- Product Citations
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Selected references: Kinzebach et al. (2013). Functional and differential proteomic analyses to identify platelet derived factors affecting ex vivo expansion of mesenchymal stromal cells. BMC Cell Biol. 2013 Oct 30;14(1):48. - Reviews:
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Accessories
IMS09-038-335 Clonality: Polyclonal Host: Hen Reactivity: Human
IMS06-038-312 | Clonality: Polyclonal | Host: Hen | Reactivity: Human
Now available only as separate products:
1 x AS16 ECL-N
1 x AS16 ECL-S
This product can be purchased in 3 different volumes:
AS16 ECL-SN-10, 10 ml. Trial size limited to one per customer
AS16 ECL-SN, 100 ml
AS16 ECL-SN-1L, 1L
Choose the appropriate volume in the drop down menu to the right