Hirudin | Refludan
IMS01-134-330 | Clonality: Polyclonal | Host: hen | Reactivity: Human
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purified full length recombinant protein (Refludan®, Hoechst Marion Roussel Inc.)
Hirudin (P01050) is a highly effective and very specific anticoagulant which specifically inhibits formation of fibrin and activation of factors V, VIII and XIII, by forming irreversible, noncovalent 1:1 complexes with alpha-thrombin. Hirudin is a 65 amino acid polypeptide, 7 kDa protein, naturally originating from the medical leech Hirudo medicinalis. It is a very potent thrombin inhibitor. Antibody binding to hirudin inhibits the interaction with alpha-thrombin.