S5a | human 26S proteasome subunit

Name: S5a | human 26S proteasome subunit
SKU: AS01 019
Price: 369 EUR
Availability: InStock

AS01 019 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Human

S5a | human 26S proteasome subunit in the group Antibodies Human Cell Biology / Other proteins at Agrisera AB (Antibodies for research) (AS01 019)

Product Information

Immunogen

Recombinant human S5a Proteasome subunit also known as Rpn10 P55036

Host Rabbit

Clonality Polyclonal

Purity Serum

Format Lyophilized

Quantity 100 µl

Reconstitution For reconstitution add 100 µl of sterile water

Storage Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Tested applications Western blot (WB)

Recommended dilution 1 : 2000 (WB)

Expected | apparent MW

40 kDa

Reactivity

Confirmed reactivity Human

Not reactive in

Drosophila melanogaster

Application examples

Additional information

Background

Proteasome-dependent degradation serves an essential role in the removal of a wide variety of key nuclear and cytosolic proteins. Substrates are targeted for proteolysis by the ubiquitin pathway before being degraded by the 26 S proteasome. The subunit of the proteasome, S5a, was identified to bind to polyubiquitin in vitro and thus proposed to act as a substrate recognition component. Alternative names: 26S proteasome non-ATPase regulatory subunit 4, Rpn10, multiubiquitin chain-binding protein, antisecretory factor 1, ASF, AF

Product citations

Selected references Lundgren et al. (2003). Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13. Mol Cel Biol 23:5320-5330.

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immunogen:	Recombinant human S5a Proteasome subunit also known as Rpn10 P55036
Reconstitution:	For reconstitution add 100 µl of sterile water
Host:	Rabbit
Clonality:	Polyclonal
Purity:	Serum
Format:	Lyophilized
Quantity:	100 µl
storage:	Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
tested applications:	Western blot (WB)
recommended dilution:	1 : 2000 (WB)
calculated \| apparent molecular mass [kDa]:	40 kDa
Confirmed reactivity:	Human
not reactive in:	Drosophila melanogaster
background:	Proteasome-dependent degradation serves an essential role in the removal of a wide variety of key nuclear and cytosolic proteins. Substrates are targeted for proteolysis by the ubiquitin pathway before being degraded by the 26 S proteasome. The subunit of the proteasome, S5a, was identified to bind to polyubiquitin in vitro and thus proposed to act as a substrate recognition component. Alternative names: 26S proteasome non-ATPase regulatory subunit 4, Rpn10, multiubiquitin chain-binding protein, antisecretory factor 1, ASF, AF
All references:	Lundgren et al. (2003). Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13. Mol Cel Biol 23:5320-5330.