LRIG1 | Lig-1 (chicken antibodies)

AS06 156 | Clonality: Polyclonal | Host: Hen | Reactivity: Human

Product Information

Immunogen

KLH-conjugated synthetic peptide; the peptide corresponds to part of the cytoplasmic tail (C-terminal part) of the protein

Host Chicken

Clonality Polyclonal

Purity Immunogen affinity purified IgY n PBS pH 8.5. Contains 0.02% sodium azide.

Format Liquid

Quantity 200 µg (1,5 µg/µl)

Storage Store at 4°C or at -20°C for long-term storage; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Tested applications Western blot (WB)

Recommended dilution 1 µg/ml (WB)

Expected | apparent MW

143 kDa

Reactivity

Confirmed reactivity Human

Predicted reactivity Human

Not reactive in Mouse

Application examples

Additional information

LRIG1 protein is migrating in denaturing polyacrylamide gel electrophoresis under reducing conditions as two species with apparent molecular weights of 143kDa and 134 kDa, and as two fragments corresponding to an N-terminal 111-kDa species and a C terminal 32-kDa species, Under non-reducing conditions,both apparent monomers and apparent higher molecular weight complexes were evident

Background

LRIG1 protein Q96JA1 is coded by a gene on a chromosome band 3p14.3, this region is known to be deleted in various human cancers. LRIG1 is considered to be a a tumour suppressor gene in humans. LRIG1 is an integral cell-surface membrane protein that is expressed by specific cells in various human tissues and that its 143-kDa form might be cleaved into 111-kDa and 32-kDa fragments. The LRIG1 protein may inhibit the growth of tumors of glial cells and the down-regulation of the LRIG1 gene may be involved in the development and progression of the tumor.

Product citations

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Confirmed reactivity:	Human
predicted reactivity:	Human
not reactive in:	Mouse
background:	LRIG1 protein Q96JA1 is coded by a gene on a chromosome band 3p14.3, this region is known to be deleted in various human cancers. LRIG1 is considered to be a a tumour suppressor gene in humans. LRIG1 is an integral cell-surface membrane protein that is expressed by specific cells in various human tissues and that its 143-kDa form might be cleaved into 111-kDa and 32-kDa fragments. The LRIG1 protein may inhibit the growth of tumors of glial cells and the down-regulation of the LRIG1 gene may be involved in the development and progression of the tumor.
additional information (application):	LRIG1 protein is migrating in denaturing polyacrylamide gel electrophoresis under reducing conditions as two species with apparent molecular weights of 143kDa and 134 kDa, and as two fragments corresponding to an N-terminal 111-kDa species and a C terminal 32-kDa species, Under non-reducing conditions,both apparent monomers and apparent higher molecular weight complexes were evident
calculated \| apparent molecular mass [kDa]:	143 kDa
Clonality:	Polyclonal
Format:	Liquid
Host:	Chicken
immunogen:	KLH-conjugated synthetic peptide; the peptide corresponds to part of the cytoplasmic tail (C-terminal part) of the protein
Purity:	Immunogen affinity purified IgY n PBS pH 8.5. Contains 0.02% sodium azide.
Quantity:	200 µg (1,5 µg/µl)
recommended dilution:	1 µg/ml (WB)
storage:	Store at 4°C or at -20°C for long-term storage; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
tested applications:	Western blot (WB)