MYST4 | histone acetyltransferase KAT6B
AS05 078 | Clonality: Polyclonal | Host: Rabbit | Reactivity:Bovine
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Black flying fox, Human (isoform 2,3), Mouse (isoform 2,3,4), Vampire bat
MYST4 (KAT6B), EC=126.96.36.199, is a transcriptional coactivator with histone acetyltransferase activity. This protein is essential for normal mouse embryo development. Mouse mutants for MYST4 show craniofacial abnormalities, retards in post-natal development, defaults in the nervous system and neurogenique problems. Abnormal chromosomic rearengements of MYST4 with the CBP gene is involved in acute myeloid leukaemia (AML)-M4. Furthermore, in the ovary and the testis of mammals, MYST4 is mainly localized in specialized cells involved in male and female gametogenesis. Alternative names: Histone acetyltransferase MOZ2, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4, Monocytic leukemia zinc finger protein-related factor.
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