MYST4 | histone acetyltransferase KAT6B

AS05 078 | Clonality: Polyclonal | Host: Rabbit | Reactivity:Bovine

Product Information

Immunogen

KLH-conjugated synthetic peptide chosen from a bovine histone acetyltrasferase MYST4 A7E390

Host Rabbit

Clonality Polyclonal

Purity Affinity purified serum

Format Lyophilized in PBS pH 7.4

Quantity 100 µg

Reconstitution For reconstitution add 125 µl of sterile water.

Storage Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.

Tested applications Imunohistochemistry (IHC) Immunoprecipitation (IP), Western blot (WB)

Recommended dilution 1 : 1000 (IHC), 1 :7500 (WB)

Expected | apparent MW

230 kDa

Reactivity

Confirmed reactivity bovine, antibody will also react with bovine MYST4 isoforms (MORF and MORF)

Predicted reactivity

Black flying fox, Human (isoform 2,3), Mouse (isoform 2,3,4), Vampire bat

Not reactive in Plants

Application examples

Additional information

Additional information Antibody has been used on extracts from bovine brain, thymus, muscle, lung, heart, liver, kidney and spleen

Blocking used in IHC was done with 5% dry milk. Secondary antibodyused: Fluorescein-conjugated goat anti-rabbit IgG (Molecular Probes) diluted 1:1000.

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Secondary antibodies

Background

MYST4 (KAT6B), EC=2.3.1.48, is a transcriptional coactivator with histone acetyltransferase activity. This protein is essential for normal mouse embryo development. Mouse mutants for MYST4 show craniofacial abnormalities, retards in post-natal development, defaults in the nervous system and neurogenique problems. Abnormal chromosomic rearengements of MYST4 with the CBP gene is involved in acute myeloid leukaemia (AML)-M4. Furthermore, in the ovary and the testis of mammals, MYST4 is mainly localized in specialized cells involved in male and female gametogenesis. Alternative names: Histone acetyltransferase MOZ2, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4, Monocytic leukemia zinc finger protein-related factor.

Product citations

Selected references McGraw et al. (2007). Investigation of MYST4 histone acetyltransferase and its involvement in mammalian gametogenesis. BMC Dev.Biol. 7:123.

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