p53 (a.a. 371-380) (clone Pab122)
AS16 4002 | Clonality: Monoclonal | Host: Mouse | Reactivity: Human, Mouse, Rat, Monkey, Hamster
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p53 is a transcription factor that acts as a tumor suppressor which cause growth arrest or apoptosis depending on different circumstances or cell type. p53 also play an important role in cell cycle regulation as a trans-activator.
The most common alteration in human cancer is disruption of the p53 signalling pathway through various mechanisms.
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