STX | saxitoxin, Total IgG (2.5 mg)
AS11 1690 | Clonality: Polyclonal | Host: Rabbit | Reactivity: saxitoxin
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Immunogen BSA-conjugated saxitoxin
Purity total IgG
Quantity 2.5 mg
Reconstitution For reconstitution add 1.1 ml of sterile water.
Storage Store at 4°C following reconstitution.
Tested applications ELISA (ELISA)
Recommended dilution The optimal working dilution should be determined by the investigator.
Confirmed reactivity Toxin from marine dinoflagellates, cyanobacteria and mussels.
Not reactive in No confirmed exceptions from predicted reactivity are currently known.
Additional information Antibodies are provided as total IgG purified on protein A. Purified antibodies were dialized against dionized water.
The term saxitoxin can also refer to the entire suite of related neurotoxins produced by these microorganisms, which include pure STX, neosaxitoxin (neoSTX), the gonyautoxins (GTX) and decarbamoylsaxitoxin (dcSTX).
Background Saxitoxin (STX) is a neurotoxin that acts as a selective sodium channel blocker and is naturally produced by certain species of marine dinoflagellates (Alexandrium sp., Gymnodinium sp., Pyrodinium sp.) and cyanobacteria (Anabaena sp., some Aphanizomenon spp., Cylindrospermopsis sp., Lyngbya sp., Planktothrix sp.). Ingestion of STX (usually through shellfish contaminated by toxic algal blooms) is responsible for the human illness known as paralytic shellfish poisoning (PSP). Saxitoxin, one of the most potent natural toxins known, acts on the voltage-gated sodium channels of nerve cells, preventing normal cellular function and leading to paralysis.
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