SCGB2A2 | Mammaglobin-A
AS03 029 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Human
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Product Information
Immunogen
KLH-conjugated 16 amino acids-long synthetic peptide derived from C-terminal sequence of human mammaglobin Q13296
Host
Rabbit
Clonality
Polyclonal
Purity
Affinity purified serum
Format
Lyophilized in PBS pH 7.4
Quantity
100 µg
Reconstitution
For reconstitution add 238 µl of sterile water.
Storage
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
Tested applications
Immunohistochemistry (IHC), Formalin/PFA-fixed paraffin-embedded sections (IHC-P), Western blot (WB)
Recommended dilution
1 µg/ml (IHC-P), 1 µg/ml (WB)
Expected | apparent MW
10.5 | 15 kDa
Reactivity
Confirmed reactivity
Human
Predicted reactivity
Human
Not reactive in
No confirmed exceptions from predicted reactivity are currently known.
Application examples
Additional information
Additional information
No cross-reactivity to lipophilin A, lipophilin B (BU101), lipophilin C (lacryglobin, mammaglobin B), or uteroglobin (Clara cell protein, Clara cell 10 kDa protein) by Western blot analysis of bacterially produced recombinant proteins. Western blot analysis of human breast cancer cells MDA-MB-415 reveals only the mammaglobin band of approximately 15 kDa. Analysis of other cells and tissues might, however, upon prolonged exposure, reveal additional bands at higher molecular weight.
Background
Background
Mammaglobin is a 93 amino acids peptide belonging to the secretoglobin superfamily. Mammaglobin is expressed by normal breast and skin tissues and is over-expressed in many human breast cancer tumours. In breast tissue, mammaglobin is expressed as a secreted heterodimer together with the other secretoglobin member lipophilin B. Protein synonymes: Mammaglobin-1, Secretoglobin family 2A member 2
Product citations
Selected references
Fischer et al. (2014). Differential expression of secretoglobins in normal ovary and in ovarian carcinoma – Overexpression of mammaglobin-1 is linked to tumor progression. Arch Biochem Biophys. 2014 Mar 3. pii: S0003-9861(14)00077-0. doi: 10.1016/j.abb.2014.02.012.
Sjödin et al (2008). Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation. Anticancer Res. 28:1493-1498.
Sjödin et al (2008). Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation. Anticancer Res. 28:1493-1498.
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