THDOC | Tetrahydrodeoxycorticosterone
AS06 192 | Clonality: Polyclonal | Host: Hen | Reactivity: THDOC
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Product Information
Immunogen
BSA-coupled THDOC
Host
Chicken
Clonality
Polyclonal
Purity
Purified, total IgY (chicken egg yolk immunoglobulin) in PBS pH 8. Contains 0.02 % sodium azide.
Format
Liquid
Quantity
100 ĩl
Storage
Store at 4°C or at -20°C for long-term storage; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Tested applications
Radioimmunoassay (RIA)
Recommended dilution
1 : 1000 (RIA)
Reactivity
Confirmed reactivity
THDOC
Not reactive in
No confirmed exceptions from predicted reactivity are currently known
Application examples
Additional information
Background
Background
TetraHydroDesOxyCorticosterone (THDOC) is a stress related neuroactive steroid. THDOC is a metabolite of desoxycoritcosterone (DOC) and progesterone and DOC is a steroid in the synthesis pathway to aldosterone. THDOC is produced by the adrenal in parallel with cortisol at stress and is regulated by ACTH. THDOC is a potent positive modulator of the GABA A receptor. THDOC passes the blood-brain barrier and can be found in the brain after stress in nanomolar concentrations.
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