THDOC | Tetrahydrodeoxycorticosterone

AS06 192 | Clonality: Polyclonal | Host: Hen | Reactivity: THDOC

Product Information

Immunogen

BSA-coupled THDOC

Host Chicken

Clonality Polyclonal

Purity Total IgY

Format Liquid in PBS pH 8.0, 0.02% sodium azide

Quantity 100 µl

Storage Store at 4°C or at -20°C for long-term storage; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.

Tested applications Radioimmunoassay (RIA)

Recommended dilution 1 : 1000 (RIA)

Reactivity

Confirmed reactivity THDOC

Not reactive in No confirmed exceptions from predicted reactivity are currently known.

Application examples

Additional information

Background

TetraHydroDesOxyCorticosterone (THDOC) is a stress related neuroactive steroid. THDOC is a metabolite of desoxycoritcosterone (DOC) and progesterone and DOC is a steroid in the synthesis pathway to aldosterone. THDOC is produced by the adrenal in parallel with cortisol at stress and is regulated by ACTH. THDOC is a potent positive modulator of the GABA A receptor. THDOC passes the blood-brain barrier and can be found in the brain after stress in nanomolar concentrations.