THP | Allopregnanolone steroid standard
AS04 041S | GMP manufactured steroid standard
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Standard dissolving instruction:
- Use ethanol (99.5 %) or methanol to prepare a concentrated (stock) solution of THP standard. This solution can be stored for longer time in a sealed tube.
- Working solution can be used daily but needs to be changed after one month.
- Working solution is used to prepare standard points 0-200 pg. It needs to be dried under nitrogen before it is diluted in water based soltion, otherwise the steroid will oxidase.
- Following dyring, water based solution can be added to this standard.
Allopregnanolone, (3alpha-hydroxy-20-oxo-5alphapregnan-11alpha-yl-carboxymethylether), also known as 3alpha,5alpha-tetrahydroprogesterone or THP, a neuroactive steroid secreted by the mammalian ovary, exerts its anesthetic, anxiolytic, and sedative/hypnotic effects through potentiation of GABA A receptors. It is produced in the human corpus luteum and their release is stimulated by trophic hormone.