THP | Allopregnanolone
AS04 041 | Clonality: Polyclonal | Host: Hen | Reactivity: Allopregnanolone
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100 µl will be enough to perform 60 double samples, generating standard curve and blank
Waters column Symmetry C18 3.5um 4.6 x 75mm with 3.9 x 20mm as guard column has been used
Allopregnanolone, (3alpha-hydroxy-5alpha-pregnan-20-ol), also known as 3alpha,5alpha-tetrahydroprogesterone or THP, is a neuroactive steroid secreted by the mammalian ovary and adrenal. It exerts its anesthetic, anxiolytic, and sedative/hypnotic effects through potentiation of GABA A receptors and its release is stimulated by trophic hormones in relation to stress and reproductive hormone secretion.
Bennett et al. (2015). Prenatal Stress Alters Hippocampal Neuroglia and Increases Anxiety in Childhood. Dev Neurosci. 2015 Aug 13.
Rault et al. (2015). Allopregnanolone and social stress: regulation of the stress response in early pregnancy in pigs. Stress. 2015 Jun 11:1-9.
Boher et al. (2014). The effects of betamethasone on allopregnanolone concentrations and brain development in preterm fetal sheep. J Exp Bot. 2013 Aug;64(11):3225-36. doi: 10.1093/jxb/ert163.