THP | Allopregnanolone

Name: THP | Allopregnanolone
SKU: AS04 041
Price: 424 EUR
Availability: InStock

AS04 041 | Clonality: Polyclonal | Host: Hen | Reactivity: Allopregnanolone

THP | Allopregnanolone in the group Antibodies Human Cell Biology / Neuroscience / Neurobiology at Agrisera AB (Antibodies for research) (AS04 041)

Product Information

Immunogen

BSA conjugated-allopregnanolone

Host Chicken

Clonality Polyclonal

Purity Purified, total IgY (chicken egg yolk immunoglobulin) in PBS pH 8. Contains 0.02 % sodium azide.

Format Liquid

Quantity 100 µl

Storage Store at 4°C; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Tested applications Radioimmunoassay (RIA)

Recommended dilution 1 : 1000 (RIA)

Reactivity

Confirmed reactivity Allopregnanolone

Not reactive in No confirmed exceptions from predicted reactivity are currently known

Application examples

Additional information

100 µl will be enough to perform 60 double samples, generating standard curve and blank

Waters column Symmetry C18 3.5um 4.6 x 75mm with 3.9 x 20mm as guard column has been used

Background

Allopregnanolone, (3alpha-hydroxy-5alpha-pregnan-20-ol), also known as 3alpha,5alpha-tetrahydroprogesterone or THP, is a neuroactive steroid secreted by the mammalian ovary and adrenal. It exerts its anesthetic, anxiolytic, and sedative/hypnotic effects through potentiation of GABA A receptors and its release is stimulated by trophic hormones in relation to stress and reproductive hormone secretion.

Product citations

Selected references Cumberland et al. (2017). Effects of combined IUGR and prenatal stress on the development of the hippocampus in a fetal guinea pig model. J Dev Orig Health Dis. 2017 May 15:1-13. doi: 10.1017/S2040174417000307.
Bennett et al. (2015). Prenatal Stress Alters Hippocampal Neuroglia and Increases Anxiety in Childhood. Dev Neurosci. 2015 Aug 13.
Rault et al. (2015). Allopregnanolone and social stress: regulation of the stress response in early pregnancy in pigs. Stress. 2015 Jun 11:1-9.
Boher et al. (2014). The effects of betamethasone on allopregnanolone concentrations and brain development in preterm fetal sheep. J Exp Bot. 2013 Aug;64(11):3225-36. doi: 10.1093/jxb/ert163.

immunogen:	BSA conjugated-allopregnanolone
Host:	Chicken
Clonality:	Polyclonal
Purity:	Purified, total IgY (chicken egg yolk immunoglobulin) in PBS pH 8. Contains 0.02 % sodium azide.
Format:	Liquid
Quantity:	100 µl
storage:	Store at 4°C; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
tested applications:	Radioimmunoassay (RIA)
recommended dilution:	1 : 1000 (RIA)
Confirmed reactivity:	Allopregnanolone
not reactive in:	No confirmed exceptions from predicted reactivity are currently known
additional information:	100 µl will be enough to perform 60 double samples, generating standard curve and blank Waters column Symmetry C18 3.5um 4.6 x 75mm with 3.9 x 20mm as guard column has been used
background:	Allopregnanolone, (3alpha-hydroxy-5alpha-pregnan-20-ol), also known as 3alpha,5alpha-tetrahydroprogesterone or THP, is a neuroactive steroid secreted by the mammalian ovary and adrenal. It exerts its anesthetic, anxiolytic, and sedative/hypnotic effects through potentiation of GABA A receptors and its release is stimulated by trophic hormones in relation to stress and reproductive hormone secretion.
All references:	Cumberland et al. (2017). Effects of combined IUGR and prenatal stress on the development of the hippocampus in a fetal guinea pig model. J Dev Orig Health Dis. 2017 May 15:1-13. doi: 10.1017/S2040174417000307. Bennett et al. (2015). Prenatal Stress Alters Hippocampal Neuroglia and Increases Anxiety in Childhood. Dev Neurosci. 2015 Aug 13. Rault et al. (2015). Allopregnanolone and social stress: regulation of the stress response in early pregnancy in pigs. Stress. 2015 Jun 11:1-9. Boher et al. (2014). The effects of betamethasone on allopregnanolone concentrations and brain development in preterm fetal sheep. J Exp Bot. 2013 Aug;64(11):3225-36. doi: 10.1093/jxb/ert163.

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