TrkA | Tyrosine Kinase Receptor A

AS13 2698 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Human, Rat, Mouse

Product Information

Immunogen Extracellular domain of glycosylated human TrkA protein produced in CHO cells was used as the immunogen,

Host Rabbit

Clonality Polyclonal

Purity Serum

Format Lyophilized

Quantity 100 µl

Reconstitution For reconstitution add 100 µl of sterile water

Storage After reconstitution keep aliquots at -20ºC for a higher stability. and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Tested applications ELISA (ELISA), Immunohistochemistry (IHC)

Recommended dilution 1 : 5000 (1-site ELISA), 1 : 1000 (IHC), Optimal dilutions/concentrations should be determined by the end user

Reactivity

Confirmed reactivity Human, Rat, Mouse

Application examples

Application examples Application example

Immunohistochemical staining of Tyrosine Kinase Receptor A (TrkA) in rat spinal cord (free floating cryostat section) using rabbit antibody (AS13 2698) at a dilution of 1 in 2000. Courtesy of Professor Xin Fu Zhou, The Flinders University of South Australia.

Additional information

Background

TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating.

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Clonality:	Polyclonal
Format:	Lyophilized
Host:	Rabbit
immunogen:	Extracellular domain of glycosylated human TrkA protein produced in CHO cells was used as the immunogen,
Purity:	Serum
Quantity:	100 µl
recommended dilution:	1 : 5000 (1-site ELISA), 1 : 1000 (IHC), Optimal dilutions/concentrations should be determined by the end user
Reconstitution:	For reconstitution add 100 µl of sterile water
storage:	After reconstitution keep aliquots at -20ºC for a higher stability. and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
tested applications:	ELISA (ELISA), Immunohistochemistry (IHC)
background:	TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating.
Picture (footer):	Application example Immunohistochemical staining of Tyrosine Kinase Receptor A (TrkA) in rat spinal cord (free floating cryostat section) using rabbit antibody (AS13 2698) at a dilution of 1 in 2000. Courtesy of Professor Xin Fu Zhou, The Flinders University of South Australia.
Confirmed reactivity:	Human, Rat, Mouse