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TrkA | Tyrosine Kinase Receptor A

AS13 2698 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Human, Rat, Mouse

TrkA | Tyrosine Kinase Receptor A in the group Antibodies for Human/Animal  / Neurosteroids/Neurobiology at Agrisera AB (Antibodies for research) (AS13 2698)

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Product Information

Immunogen

Extracellular domain of glycosylated human TrkA protein produced in CHO cells was used as the immunogen.

Host Rabbit
Clonality Polyclonal
Purity Serum
Format Lyophilized
Quantity 100 ĩl
Reconstitution For reconstitution add 100 ĩl of sterile water.
Storage

After reconstitution keep aliquots at -20ºC for a higher stability, and at  4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Tested applications ELISA (ELISA), Immunohistochemistry (IHC)
Recommended dilution 1 : 5000 (1-site ELISA), 1 : 1000 (IHC). Optimal dilutions/concentrations should be determined by the end user.

Reactivity

Confirmed reactivity Human, Rat, Mouse

Application examples

Application examples Application example



Immunohistochemical staining of Tyrosine Kinase Receptor A (TrkA) in rat spinal cord (free floating cryostat section) using rabbit antibody (AS13 2698) at a dilution of 1 in 2000. Courtesy of Professor Xin Fu Zhou, The Flinders University of South Australia.







Additional information

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Background

Background

TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating.

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