TrkB | Tyrosine Kinase Receptor B

Name: TrkB | Tyrosine Kinase Receptor B
Brand: IKP
SKU: AS13 2697
Price: 331 EUR
Availability: InStock

AS13 2697 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Rat, Mouse

TrkB | Tyrosine Kinase Receptor B in the group Antibodies Human Cell Biology / Neuroscience / Neurobiology at Agrisera AB (Antibodies for research) (AS13 2697)

Product Information

Immunogen Extracellular domain of glycosylated mouse TrkB protein produced in CHO cells was used as the immunogen, As shown for similar antisera, it is anticipated that this antibody will block the TrkB receptor binding of corresponding neurotrophin ligand,

Host Rabbit

Clonality Polyclonal

Purity Serum

Format Lyophilized

Quantity 100 µl

Reconstitution For reconstitution add 100 µl of sterile water

Storage After reconstitution keep aliquots at -20ºC for a higher stability. and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Tested applications ELISA (ELISA), Immunohistochemistry (IHC)

Recommended dilution 1 : 10 000 (1-site ELISA), 1 : 1000-1 : 3000 (IHC), Optimal dilutions/concentrations should be determined by the end user

Reactivity

Confirmed reactivity Rat, Mouse

Application examples

Application examples Application example

Immunohistochemical staining of Tyrosine Kinase Receptor B (TrkB) in rat ventral horn (free floating cryostat section) using rabbit antibody (AS13 2697) at a dilution of 1 in 3000. Courtesy of Professor Xin Fu Zhou, The Flinders University of South Australia

Additional information

Background

TrkB is a member of the neurotrophic tyrosine receptor kinase family. It is a membrane-bound receptor and upon neurotrophin binding, it phosphorylates itself as well as MAPK pathways members. TrkB is the receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). It is Involved in the development and/or maintenance of the nervous system.

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immunogen:	Extracellular domain of glycosylated mouse TrkB protein produced in CHO cells was used as the immunogen, As shown for similar antisera, it is anticipated that this antibody will block the TrkB receptor binding of corresponding neurotrophin ligand,
Reconstitution:	For reconstitution add 100 µl of sterile water
Host:	Rabbit
Clonality:	Polyclonal
Purity:	Serum
Format:	Lyophilized
Quantity:	100 µl
storage:	After reconstitution keep aliquots at -20ºC for a higher stability. and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
tested applications:	ELISA (ELISA), Immunohistochemistry (IHC)
recommended dilution:	1 : 10 000 (1-site ELISA), 1 : 1000-1 : 3000 (IHC), Optimal dilutions/concentrations should be determined by the end user
Confirmed reactivity:	Rat, Mouse
Picture (footer):	Application example Immunohistochemical staining of Tyrosine Kinase Receptor B (TrkB) in rat ventral horn (free floating cryostat section) using rabbit antibody (AS13 2697) at a dilution of 1 in 3000. Courtesy of Professor Xin Fu Zhou, The Flinders University of South Australia
background:	TrkB is a member of the neurotrophic tyrosine receptor kinase family. It is a membrane-bound receptor and upon neurotrophin binding, it phosphorylates itself as well as MAPK pathways members. TrkB is the receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). It is Involved in the development and/or maintenance of the nervous system.