TrkB | Tyrosine Kinase Receptor B
AS13 2697 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Rat, Mouse

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Product Information
Immunogen
Extracellular domain of glycosylated mouse TrkB protein produced in CHO cells was used as the immunogen, As shown for similar antisera, it is anticipated that this antibody will block the TrkB receptor binding of corresponding neurotrophin ligand,
Host
Rabbit
Clonality
Polyclonal
Purity
Serum
Format
Lyophilized
Quantity
100 ĩl
Reconstitution
For reconstitution add 100 ĩl of sterile water
Storage
After reconstitution keep aliquots at -20šC for a higher stability. and at 4šC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Tested applications
ELISA (ELISA), Immunohistochemistry (IHC)
Recommended dilution
1 : 10 000 (1-site ELISA), 1 : 1000-1 : 3000 (IHC), Optimal dilutions/concentrations should be determined by the end user
Reactivity
Confirmed reactivity
Rat, Mouse
Application examples
Application examples
Application example

Immunohistochemical staining of Tyrosine Kinase Receptor B (TrkB) in rat ventral horn (free floating cryostat section) using rabbit antibody (AS13 2697) at a dilution of 1 in 3000. Courtesy of Professor Xin Fu Zhou, The Flinders University of South Australia

Immunohistochemical staining of Tyrosine Kinase Receptor B (TrkB) in rat ventral horn (free floating cryostat section) using rabbit antibody (AS13 2697) at a dilution of 1 in 3000. Courtesy of Professor Xin Fu Zhou, The Flinders University of South Australia
Additional information
Background
Background
TrkB is a member of the neurotrophic tyrosine receptor kinase family. It is a membrane-bound receptor and upon neurotrophin binding, it phosphorylates itself as well as MAPK pathways members. TrkB is the receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). It is Involved in the development and/or maintenance of the nervous system.
Product citations
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