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FVIIa | Coagulation factor VIIa (500 ĩg)

1600 €

AS00 001-500  |  clonality: polyclonal  |  host: rabbit  |  reactivity: human 

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AS00 001-500

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product information
Background

Factor VIIa (FVIIa) is a key serine protease involved in the initiation of the coagulation cascade. FVIIa requires tissue factor (TF), a membrane bound protein, as an essential cofactor for maximal activity towards its biological substrates Factor X, Factor IX and Factor VII (FVII).

Immunogen

Recombinant human Factor VIIa (NovoSeven ®, Novo Nordisk  A/S Denmark)

Host Rabbit
Clonality Polyclonal
Clone
Purity Affinity purified IgG in PBS, pH 7.4
Format Lyophilized
Quantity

500 ug

Reconstitution For reconstitution add 500 µl of sterile water.
Storage Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them, to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
Tested applications Prothrombin assay with human plasma (PT), thrombin generation assay, inhibition assay with Factor VIIa with TF and a chromogenic substrate, inDirect ELISA (I-ELISA)
Related products

AS00 001 | FVIIa | Coagulation factor VIIa (50 µg)

IMS01-015-308 | F8 | Coagulation factor VIII

IMS01-118-307 | F7 | Coagulation factor VII

IMS01-137-306 | F12 | Coagulation factor XII

Secondary antibodies

Additional information No significant difference in binding to Factor VII and Factor VIIa.

Antibody is purified to total IgG fraction, followed by purification on specific FVIIa column.
application information
Recommended dilution 1 : 15 000 (I-ELISA)
Expected | apparent MW

52 kDa

Confirmed reactivity Human
Predicted reactivity Primates
Not reactive in No confirmed exceptions from predicted reactivity are currently known.
Additional information
Selected references Lopez-Vilchez et al. (2009). Traffic of rFVIIa through Endothelial Cells and Redistribution into Subendothelium: Implications for a Prolonged Hemostatic Effect. Journal of Coagulation Disorders, October 1: (1). (immunolocalization)


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