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8-Hydroxyguanosine | DNA/RNA oxidative damage (25 ĩg)

194 €

AS10 708-25  | clonality: monoclonal  |  host: mouse  |  reactivity: 8-hydroxyguanosine

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AS10 708-25

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product information
Background

Oxidative derivate of guanosine is called 8-Hydroxyguanosine (8OHdG) and is used as a popular biomarker of oxidative stress.

Immunogen

8-hydroxy-guanosine-BSA and – casein conjugates

Host Mouse
Clonality Monoclonal
Clone IgG2A (clone 15A3)
Purity
Format Liquid
Quantity 25 ĩg
Reconstitution
Storage

store at -20°C; avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.

Tested applications ELISA (ELISA), immunostaining on frozen tissue and paraffin-embedded (IHC-Fr-P), affinity purification (AP)
Related products

AS10 708-100 | hydroxy guanosine monoclonal antibody, 100 µg

Secondary antibodies

Additional information

protein G purified IgG2B in PBS, pH 7.4 with 0.09 % sodium azide and 50 % glycerol at concentration 0.65 mg/ml

application information
Recommended dilution

needs to be determined for each application

Expected | apparent MW
Confirmed reactivity

Recognizes markers of oxidative damage to DNA (8-hydroxy-2’-deoxyguanosine, 8-hydroxyguanine and 8-hydroxyguanosine)

Predicted reactivity
Not reactive in

no confirmed exceptions from predicted reactivity known in the moment

Additional information

protocol for immunostaining using this antibody can be found here

Selected references Haigh and Drew (2015). Cavitation during the protein misfolding cyclic amplification (PMCA) method - The trigger for de novo prion generation? Biochem Biophys Res Commun. 2015 Apr 17. pii: S0006-291X(15)00726-3. doi: 10.1016/j.bbrc.2015.04.048.
Poborilova et al. (2015). DNA hypomethylation concomitant with the overproduction of ROS induced by naphthoquinone juglone on tobacco BY-2 suspension cells. Environmental and Experimental Botany, Volume 113, May 2015, Pages 28–39.


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