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ASyO5-biotinylated | Mouse anti-human alpha-synuclein | oligomer-specific

540 €

AS13 2718B  | clonality: monoclonal  |  host: mouse  |  reactivity: human

 

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AS13 2718B

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product information
Background

Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed.  

Immunogen

synthetic peptide derived from human alpha-synuclein Gly111–Tyr125 

Host Mouse
Clonality Monoclonal
Clone IgG1
Purity Affinity purified
Format Lyophilized
Quantity 50 ĩg
Reconstitution For reconstitution add 50 ĩl of sterile water.
Storage

store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.

Tested applications ELISA (ELISA)
Related products

AS13 2718 | anti-ASyO5 | Mouse anti-human alpha-synuclein | oligomer-specific, monoclonal antibodies
AS13 2719 | anti-ASyM | Mouse anti-human alpha synuclein N-terminal, monoclonal antibodies

AS13 2717B | anti-ASyO2-biotinylated | Mouse anti-human alpha-synuclein | oligomer-specific, monoclonal antibodies
AS13 2719B | anti-ASyM-biotinylated | Mouse anti-human alpha synuclein N-terminal, monoclonal antibodies

AS08 358 | anti-SNCA | Alpha-synuclein, rabbit antibodies

Secondary antibodies

Additional information

antibody is biotinylated

application information
Recommended dilution

2-4 ug/ml (ELISA)

Expected | apparent MW

14 kDa

Confirmed reactivity human
Predicted reactivity n.a.
Not reactive in

no confirmed exceptions from predicted reactivity are currently known

Additional information
Selected references Brännström et al. (2014). A Generic Method for Design of Oligomer-Specific Antibodies. PLoS ONE. DOI: 10.1371/journal.pone.0090857.

 



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