Anti-ASyO2-biotinylated | Mouse anti-human alpha-synuclein | oligomer-specific
AS13 2717B | Clonality: monoclonal | Host: Mouse | Reactivity: Human
- Product Info
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Sub class: IgG1 Immunogen: Synthetic peptide derived from human alpha-synuclein Glu131-Ala140 Host: Mouse Clonality: Monoclonal Purity: Immunogen affinity purified serum in PBS pH 7.4. Format: Lyophilized Quantity: 50 µg Reconstitution: For reconstitution add 50 µl of sterile water Storage: For short time storage add sodium azide and store at +4°C. For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube. Tested applications: ELISA (ELISA) Recommended dilution: 2-4 µg/ml (ELISA) Expected | apparent MW: 14 kDa
- Reactivity
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Confirmed reactivity: Human Not reactive in: No confirmed exceptions from predicted reactivity are currently known - Additional Information
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Additional information: Antibody is biotinylated - Background
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Background: Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed.
- Product Citations
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Selected references: Brännström et al. (2014). A Generic Method for Design of Oligomer-Specific Antibodies. PLoS ONE. DOI: 10.1371/journal.pone.0090857. - Protocols
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Accessories
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AS09 627 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Mouse IgG (H&L)
AS13 2718B | Clonality: monoclonal | Host: Mouse | Reactivity: Human