ASyO5-biotinylated | Mouse anti-human alpha-synuclein | oligomer-specific
AS13 2718B | Clonality: monoclonal | Host: Mouse | Reactivity: Human
- Product Info
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Sub class: IgG1 Immunogen: Synthetic peptide derived from human alpha-synuclein Gly111-Tyr125 Host: Mouse Clonality: Monoclonal Purity: Immunogen affinity purified serum in PBS pH 7.4. Format: Lyophilized Quantity: 50 µg Reconstitution: For reconstitution add 50 µl of sterile water Storage: Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube. Tested applications: ELISA (ELISA) Recommended dilution: 2-4 µg/ml (ELISA) Expected | apparent MW: 14 kDa
- Reactivity
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Confirmed reactivity: Human - Application Examples
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- Additional Information
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Additional information: Antibody is biotinylated Additional information (application): Preparation of α-synuclein oligomers and fibrils is described here. - Background
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Background: Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed.
- Product Citations
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Selected references: Brännström et al. (2014). A Generic Method for Design of Oligomer-Specific Antibodies. PLoS ONE. DOI: 10.1371/journal.pone.0090857. - Protocols
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- Reviews:
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Accessories
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