ASyO5-biotinylated | Mouse anti-human alpha-synuclein | oligomer-specific
AS13 2718B | Clonality: monoclonal | Host: Mouse | Reactivity: Human
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synthetic peptide derived from human alpha-synuclein Gly111–Tyr125
Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed.