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ASyO5-biotinylated | Mouse anti-human alpha-synuclein | oligomer-specific

AS13 2718B  | Clonality: monoclonal  |  Host: Mouse  |  Reactivity: Human

ASyO5-biotinylated |  Mouse anti-human alpha-synuclein | oligomer-specific in the group Antibodies Human Cell Biology / Neuroscience / Neurodegenerative diseases / Parkinson's disease at Agrisera AB (Antibodies for research) (AS13 2718B)



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Product Information

Immunogen synthetic peptide derived from human alpha-synuclein Gly111-Tyr125
Host Mouse
Clonality Monoclonal
Subclass/isotype IgG1
Purity Immunogen affinity purified serum in PBS pH 7.4.
Format Lyophilized
Quantity 50 ĩg
Reconstitution For reconstitution add 50 ĩl of sterile water
Storage Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Tested applications ELISA (ELISA)
Recommended dilution 2-4 ug/ml (ELISA)
Expected | apparent MW

14 kDa

Reactivity

Confirmed reactivity Human

Application examples

Application examples

 


Additional information

Additional information Antibody is biotinylated
Preparation of α-synuclein oligomers and fibrils is described here.

Related products

Related products

AS13 2718 | Anti-ASyO5 | Mouse anti-human alpha-synuclein | oligomer-specific, monoclonal antibodies
AS13 2719 | Anti-ASyM | Mouse anti-human alpha synuclein N-terminal, monoclonal antibodies

AS13 2717B | Anti-ASyO2-biotinylated | Mouse anti-human alpha-synuclein | oligomer-specific, monoclonal antibodies
AS13 2719B | Anti-ASyM-biotinylated | Mouse anti-human alpha synuclein N-terminal, monoclonal antibodies

AS08 358 | Anti-SNCA | Alpha-synuclein, rabbit antibodies

Secondary antibodies

Background

Background

Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed.  

Product citations

Selected references Brännström et al. (2014). A Generic Method for Design of Oligomer-Specific Antibodies. PLoS ONE. DOI: 10.1371/journal.pone.0090857.

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