ASyM-biotinylated | Mouse anti-human alpha synuclein N-terminal

Name: ASyM-biotinylated | Mouse anti-human alpha synuclein N-terminal
SKU: AS13 2719B
Price: 618 EUR
Availability: InStock

AS13 2719B | Clonality: monoclonal | Host: Mouse | Reactivity: Human

ASyM-biotinylated | Mouse anti-human alpha synuclein N-terminal in the group Antibodies Human Cell Biology / Neuroscience / Neurodegenerative diseases / Parkinson's disease at Agrisera AB (Antibodies for research) (AS13 2719B)

Product Information

Immunogen

synthetic peptide derived from human alpha-synuclein N-terminal Met1-Val15

Host Mouse

Clonality Monoclonal

Subclass/isotype IgG2a

Purity Immunoglobulin affinity purified in PBS pH 7.4.

Format Lyophilized

Quantity 50 µg

Reconstitution For reconstitution add 50 µl of sterile water

Storage For short time storage add sodium azide and store at +4°C. For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Tested applications ELISA (ELISA)

Recommended dilution 2-4 ug/ml (ELISA capture)

Expected | apparent MW

14 kDa

Reactivity

Confirmed reactivity Human

Not reactive in No confirmed exceptions from predicted reactivity are currently known

Application examples

Additional information

This antibody is biotinylated.

Cross reactivity of this antibody to synuclein beta was not determined.

Background

Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed.

Product citations

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immunogen:	synthetic peptide derived from human alpha-synuclein N-terminal Met1-Val15
Sub class:	IgG2a
Host:	Mouse
Clonality:	Monoclonal
Purity:	Immunoglobulin affinity purified in PBS pH 7.4.
Format:	Lyophilized
Quantity:	50 µg
Reconstitution:	For reconstitution add 50 µl of sterile water
storage:	For short time storage add sodium azide and store at +4°C. For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Tested applications:	ELISA (ELISA)
recommended dilution:	2-4 ug/ml (ELISA capture)
Expected \| apparent MW:	14 kDa
Confirmed reactivity:	Human
not reactive in:	No confirmed exceptions from predicted reactivity are currently known
additional information:	This antibody is biotinylated. Cross reactivity of this antibody to synuclein beta was not determined.
background:	Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed.