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ASyM | Mouse anti-human alpha synuclein N-terminal (clone number 4,2)

AS13 2719  | Clonality: monoclonal  |  Host: Mouse  |  Reactivity: Human

ASyM | Mouse anti-human alpha synuclein N-terminal  (clone number 4,2) in the group Antibodies Human Cell Biology / Neuroscience / Neurodegenerative diseases / Parkinson's disease at Agrisera AB (Antibodies for research) (AS13 2719)



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Product Information

Immunogen

synthetic peptide derived from human alpha-synuclein N-terminal Met1-Val15

Host Mouse
Clonality Monoclonal
Subclass/isotype IgG2a
Purity Immunogen affinity purified serum in PBS pH 7.4.
Format Lyophilized
Quantity 50 ĩg
Reconstitution For reconstitution add 50 ĩl of sterile water
Storage For short time storage add sodium azide and store at +4°C. For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Tested applications Dot blot (Dot), ELISA (ELISA), Immunohistochemistry (IHC)
Recommended dilution 1-2 ug/ml (Dot), 2-4 ug/ml (ELISA capture), 10 ug/ml (IHC)
Expected | apparent MW

14 kDa

Reactivity

Confirmed reactivity Human
Predicted reactivity Mouse
Not reactive in No confirmed exceptions from predicted reactivity are currently known

Application examples

Additional information

Additional information

This antibody will recognize human SNCA monomers and multimers in Western blot.

This antibody binds weakly to fibrills in IHC.

Cross reactivity of this antibody to synuclein beta was not determined.

This antibody can be used as a capture antibody in ELISA, combined with AS08 358 as a detection antibody. 

Related products

Related products

AS13 2718 | anti-ASyO5 | Mouse anti-human alpha-synuclein | oligomer-specific, monoclonal antibodies
AS13 2717B | anti-ASyO2-biotinylated | Mouse anti-human alpha-synuclein | oligomer-specific, monoclonal antibodies
AS13 2718B | anti-ASyO5-biotinylated |  Mouse anti-human alpha-synuclein | oligomer-specific, monoclonal antibodies
AS13 2719B | anti-ASyM-biotinylated | Mouse anti-human alpha synuclein N-terminal, monoclonal antibodies
AS08 358 | anti-SNCA | Alpha-synuclein, rabbit antibodies

Background

Background

Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy.

Product citations

Selected references Tanudjojo et al. (2021) Phenotypic manifestation of ?-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons. Nat Commun. 2021 Jun 21;12(1):3817. doi: 10.1038/s41467-021-23682-z. PMID: 34155194; PMCID: PMC8217249.

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