SNCA | Alpha-synuclein

AS08 358  |  Clonality: Polyclonal  |  Host: Rabbit  |  Reactivity: Human

SNCA | Alpha-synuclein in the group Antibodies Human Research / Neuroscience / Neurodegenerative diseases / Parkinson's disease at Agrisera AB (Antibodies for research) (AS08 358)


How to cite this product:
Product name, number (Agrisera, Sweden)

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Product Information

Immunogen recombinant, full length, human alpha-synuclein UniProt: P37840, epitope was mapped between amino acid 1-15
Host Rabbit
Clonality Polyclonal
Purity Serum
Format Lyophilized
Quantity 100 ĩl
Reconstitution For reconstitution add 100 ĩl of sterile water
Storage Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Tested applications ELISA (ELISA), Immunolocalization (IL), Western blot (WB)
Recommended dilution 1 : 3000 (ELISA), 1-2 µg/ml (IL), 1 : 1000 (WB)
Expected | apparent MW

14 kDa


Confirmed reactivity Human
Predicted reactivity Primates, Chimpanzee, Gorilla

Application examples

Application examples

Western analysis

• Membrane: Nitrocellulose
• Blocking buffer: 5% dry milk in PBS, 0.15% tween 20
• Antibody dilution: 1:1000
• Secondary antibody: anti-rabbit (HRP)
• Detection: Enhanced Chemoluminescence (pico) 10s



1. Cell lysate lacking alpha-synuclein 10 000 ng (negative control)
2. Human plasma 10 000 ng (negative control)
3. Human alpha-synuclein 100 ng
4. Human alpha-synuclien 10 ng

Additional information

Additional information

Immunolocalization: human tissue was paraffin-embedded and sectioned. De-waxed and rehydrated in an ethanol gradient. Antigens were retrieved in sodium citrate buffer (pH 6) at 95°C for 1 h. The tissue sections were separately incubated for 1 h at RT with primary antibody and antibody binding was visualized with IgG Preoxidase Reagent Kit.

This antibody will recognize human SNCA monomers and multimers in Western blot.

In ELISA this antibody can be used for detection, combined with AS13 2719 as a capture antibody. 

Related products

Related products

AS13 2718 | Anti-ASyO5 | Mouse anti-human alpha-synuclein | oligomer-specific, monoclonal antibodies
AS13 2719 | Anti-ASyM | Mouse anti-human alpha synuclein N-terminal, monoclonal antibodies

AS13 2717B | Anti-ASyO2-biotinylated | Mouse anti-human alpha-synuclein | oligomer-specific, monoclonal antibodies
AS13 2718B | Anti-ASyO5-biotinylated |  Mouse anti-human alpha-synuclein | oligomer-specific, monoclonal antibodies
AS13 2719B | Anti-ASyM-biotinylated | Mouse anti-human alpha synuclein N-terminal, monoclonal antibodies

Secondary antibodies



Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy.

Product citations

Selected references Bargar et al. (2021) Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories. Mol Neurodegener. 2021 Dec 11;16(1):82. doi: 10.1186/s13024-021-00491-y. PMID: 34895275; PMCID: PMC8665327.
Brännström et al. (2014). A generic method for design of oligomer-specific antibodies. PLoS One. 2014 Mar 11;9(3):e90857. doi: 10.1371/journal.pone.0090857. eCollection 2014.

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