FVIIa | Coagulation factor VIIa (50 ĩg)
AS00 001 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Human

Data sheet | Product citations | Add review |
Product Information
Immunogen
Recombinant human Factor VIIa (NovoSeven ®, Novo Nordisk A/S Denmark)
Host
Rabbit
Clonality
Polyclonal
Purity
Immunogen affinity purified IgG in PBS pH 7.4.
Format
Lyophilized
Quantity
50 ĩg
Reconstitution
For reconstitution add 50 µl of sterile water
Storage
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them, to avoid any losses that might occur from material adhering to the cap or sides of the tube.
Tested applications
Prothrombin assay with human plasma (PT), thrombin generation assay, inhibition assay with Factor VIIa with TF and a chromogenic substrate, inDirect ELISA (I-ELISA)
Recommended dilution
1 : 15 000 (I-ELISA), 14 µg/ml (IL)
Expected | apparent MW
52 kDa (this is MW of Factor VIIa)
Reactivity
Confirmed reactivity
Human
Predicted reactivity
Primates
Not reactive in
No confirmed exceptions from predicted reactivity are currently known
Application examples
Additional information
Additional information
No significant difference in binding to Factor VII and Factor VIIa.
Antibody is purified to total IgG fraction, followed by purification on specific FVIIa column.
Antibody is purified to total IgG fraction, followed by purification on specific FVIIa column.
This antibody is purified using Protein G, to obtain a total IgG fraction
Background
Background
Factor VIIa (FVIIa) is a key serine protease involved in the initiation of the coagulation cascade. FVIIa requires tissue factor (TF), a membrane bound protein, as an essential cofactor for maximal activity towards its biological substrates Factor X, Factor IX and Factor VII (FVII).
Product citations
Selected references
Lopez-Vilchez et al. (2009). Traffic of rFVIIa through Endothelial Cells and Redistribution into Subendothelium: Implications for a Prolonged Hemostatic Effect. Journal of Coagulation Disorders, October 1: (1). (immunolocalization)
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