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Transthyretin 39-44, amyloid specific

AS16 3112   | Clonality: monoclonal  |  Host: Mouse  |  Reactivity: Human

Transthyretin 39-44, amyloid specific  in the group Antibodies for Human/Animal  / Human Proteins / Amyloid disorders / Alzheimer's disease at Agrisera AB (Antibodies for research) (AS16 3112)

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Product Information

Immunogen

Full length variant TTR. 

Host Mouse
Clonality Monoclonal
Subclass/isotype IgG
Purity Affinity purified
Format Lyophilized
Quantity 100 µg
Reconstitution For reconstitution add 100 µl of sterile water.
Storage

For short time storage please add sodium azide and srote at +4°C.
For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.

Tested applications ELISA (ELISA), Immunohistochemistry (IHC), Western blot (WB)
Recommended dilution

5 μg/ml (ELISA), 2 µg/ml (WB), 5 µg/ml (IHC)

Reactivity

Confirmed reactivity Human
Not reactive in No confirmed exceptions from predicted reactivity are currently known.

Application examples

Application examples


Additional information

Related products

Related products

AS16 3113 | Mouse IgG anti-transthyretin 56-61 (amyloid specific), mouse monoclonal antibodies

Background

Background

Transthyretin is a carrier protein in plasma of the thyroid hormone. This protein forms a complex with retinol-binding protein and it has the capability of forming amyloid fibrils. 25% of individuals older than 80 years are affected by senile systemic amyloidosis and most cases of TTR-associated amyloidosis are linked to point mutations. A substitution of valine for methionine at position 30 of the 127-aa-long polypeptide is one of the most common forms, leading to many symptoms in the peripheral nervous system, a familial amyloidosis with polyneuropathy.

This monoclonal IgG1 antibody is amyloid specific for human Transthyretin. Detects the N-terminal fragment TTR-1-48 frequently formed in vivo.

Product citations

Selected references Goldsteins et al. (1999). Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6): 3108–3113

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