Transthyretin 39-44, amyloid specific (mouse monoclonal)

Name: Transthyretin 39-44, amyloid specific (mouse monoclonal)
SKU: AS16 3112
Price: 373 EUR
Availability: InStock

AS16 3112 | Clonality: monoclonal | Host: Mouse | Reactivity: Human

Transthyretin 39-44, amyloid specific (mouse monoclonal) in the group Antibodies Human Cell Biology / Neuroscience / Neurodegenerative diseases / Alzheimer's disease at Agrisera AB (Antibodies for research) (AS16 3112)

Product Information

Immunogen Full length variant TTR,

Host Mouse

Clonality Monoclonal

Subclass/isotype IgG

Purity Affinity purified in PBS pH 7.4.

Format Lyophilized

Quantity 100 µg

Reconstitution For reconstitution add 100 µl of sterile water

Storage For short time storage please add sodium azide and srote at +4°C.For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Tested applications ELISA (ELISA), Immunohistochemistry (IHC), Western blot (WB)

Recommended dilution

5 μg/ml (ELISA), 2 µg/ml (WB), 5 µg/ml (IHC)

Reactivity

Confirmed reactivity Human

Not reactive in No confirmed exceptions from predicted reactivity are currently known

Application examples

Additional information

Background

Transthyretin is a carrier protein in plasma of the thyroid hormone. This protein forms a complex with retinol-binding protein and it has the capability of forming amyloid fibrils. 25% of individuals older than 80 years are affected by senile systemic amyloidosis and most cases of TTR-associated amyloidosis are linked to point mutations. A substitution of valine for methionine at position 30 of the 127-aa-long polypeptide is one of the most common forms, leading to many symptoms in the peripheral nervous system, a familial amyloidosis with polyneuropathy.

This monoclonal IgG1 antibody is amyloid specific for human Transthyretin. Detects the N-terminal fragment TTR-1-48 frequently formed in vivo.

Product citations

Selected references Goldsteins et al. (1999). Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6): 3108–3113

Related products: Transthyretin 39-44, amyloid specific (mouse monoclonal)

Agrisera ECL kit (Bright/SuperBright)

AS16 ECL-S-N | low pico to mid femtogram and extreme low femtogram detection

This product can b...

From 26 €

Info

Add to cart

Goat anti-Mouse IgG (H&L), ALP conjugated

AS10 1159 | Clonality: Polyclonal | Host: Goat | Reactivity: Mouse ...

233 €

Goat anti-Mouse IgG (H&L), HRP conjugated

AS11 1772 | Clonality: Polyclonal | Host: Goat | Reactivity: Mouse IgG (H&L)

10 % until en...

167 €

Transthyretin 56-61, amyloid specific (mouse monoclonal)

AS16 3113 | clonality: monoclonal | host: mouse | reactiv...

353 €

immunogen:	Full length variant TTR,
Reconstitution:	For reconstitution add 100 µl of sterile water
Sub class:	IgG
Host:	Mouse
Clonality:	Monoclonal
Purity:	Affinity purified in PBS pH 7.4.
Format:	Lyophilized
Quantity:	100 µg
storage:	For short time storage please add sodium azide and srote at +4°C.For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
tested applications:	ELISA (ELISA), Immunohistochemistry (IHC), Western blot (WB)
recommended dilution:	5 μg/ml (ELISA), 2 µg/ml (WB), 5 µg/ml (IHC)
Confirmed reactivity:	Human
not reactive in:	No confirmed exceptions from predicted reactivity are currently known
Picture (footer):
background:	Transthyretin is a carrier protein in plasma of the thyroid hormone. This protein forms a complex with retinol-binding protein and it has the capability of forming amyloid fibrils. 25% of individuals older than 80 years are affected by senile systemic amyloidosis and most cases of TTR-associated amyloidosis are linked to point mutations. A substitution of valine for methionine at position 30 of the 127-aa-long polypeptide is one of the most common forms, leading to many symptoms in the peripheral nervous system, a familial amyloidosis with polyneuropathy. This monoclonal IgG1 antibody is amyloid specific for human Transthyretin. Detects the N-terminal fragment TTR-1-48 frequently formed in vivo.
All references:	Goldsteins et al. (1999). Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6): 3108–3113