Transthyretin 39-44, amyloid specific (mouse monoclonal)

5 μg/ml (ELISA), 2 µg/ml (WB), 5 µg/ml (IHC)

Transthyretin is a carrier protein in plasma of the thyroid hormone. This protein forms a complex with retinol-binding protein and it has the capability of forming amyloid fibrils. 25% of individuals older than 80 years are affected by senile systemic amyloidosis and most cases of TTR-associated amyloidosis are linked to point mutations. A substitution of valine for methionine at position 30 of the 127-aa-long polypeptide is one of the most common forms, leading to many symptoms in the peripheral nervous system, a familial amyloidosis with polyneuropathy.

This monoclonal IgG1 antibody is amyloid specific for human Transthyretin. Detects the N-terminal fragment TTR-1-48 frequently formed in vivo.