Staphylococcal Protein A, FITC-conjugated
AS20 4471 | Clonality: Polyclonal | Host: Chicken | Reactivity: Staphylococcus aureus Protein A
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Recombinant Protein A
Antibodies were isolated from immune eggs, affinity purified on a Protein A column and conjugated to fluoroscein isothiocyanate (FITC).
Protein A is a surface protein of S. aureus which binds IgG molecules by their Fc region. In serum, the bacteria will bind IgG molecules in the wrong orientation on their surface, which hinders opsonization and phagocytosis. Mutants of S. aureus lacking protein A are more efficiently phagocytosed in vitro and mutants in infection models have diminished virulence. Due to its affinity for the Fc region of many mammalian immunoglobulins, protein A is considered a universal reagent in biochemistry and immunology.