Recombinant Antibodies and Multiclonals: what are they?

Recombinant Antibodies & Multiclonals Explained

Recombinant antibodies are produced by selecting antibodies that recognize specific epitopes (regions of a target antigen). The selected antibodies are then sequenced, cloned, and expressed in suitable host cells to produce consistent, well-defined antibodies.

Multiclonals are mixtures of recombinant antibodies, each designed to recognize a specific, selected epitope on the target antigen. By combining multiple recombinant antibodies, multiclonals can recognize several epitopes on the same target.

Advantages:

• High reproducibility: Minimal batch-to-batch variation ensures consistent performance.

• Scalable production: Antibodies can be produced in large quantities with consistent quality.

• Defined composition: Recombinant production allows precise control over antibody identity and composition.

Limitations:

• Higher cost: Development and production can be more expensive compared with conventional antibodies.

IgG molecule