Acetylated lysine (25 ĩl, clone 7F8)
AS10 707-25 | Clonality: monoclonal | Host: Mouse | Reactivity: acetylated lysine

Data sheet | Product citations | Add review |
Product Information
acetylated KLH
Reactivity
Application examples
Additional information
1 µg of this antibody is sufficient to detect acetylated chicken erythrocyte histones (sodium butyrate-treated) using 20 µg total protein and ECL detection system
Background
Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common posttranscriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine Nε-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization (3).
Product citations
Related products: Acetylated lysine (25 ĩl, clone 7F8)
Now available only...