Acetylated lysine (25 ĩl)

AS10 707-25  | Clonality: monoclonal  |  Host: Mouse  |  Reactivity: acetylated lysine

Acetylated lysine (25 ĩl) in the group Plant/Algal Antibodies / DNA/RNA/Cell Cycle / Epigenetics/DNA methylation at Agrisera AB (Antibodies for research) (AS10 707-25)


199 €

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product information

Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common posttranscriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine Nε-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization (3).  


acetylated KLH

Host Mouse
Clonality Monoclonal
Clone IgG1 (clone 7F8)
Purity Protein G purified
Format Liquid
Quantity 25 ĩl
Storage Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
Tested applications ELISA (ELISA), Immunocytochmistry/Immunofluorescence (ICC/IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western blot (WB)
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collection of antibodies to epigenetics

Secondary antibodies

Additional information Protein G purified IgG2B in PBS, pH 7.4 with 0.09 % sodium azide and 50 % glycerol at concentration 1 mg/mlantibody detects Proteins containing acetylated lysine residues in ELISA and WBs. Does not detect non-acetylated lysine residues.
application information
Recommended dilution 1 : 100 (IHC), 1 : 1000 (WB)
Expected | apparent MW
Confirmed reactivity Bovine, avian
Predicted reactivity Higher plants
Not reactive in No confirmed exceptions from predicted reactivity are currently known.
Additional information

1 µg of this antibody is sufficient to detect acetylated chicken erythrocyte histones (sodium butyrate-treated) using 20 µg total protein and ECL detection system

Selected references Vigushin & Coombes (2004). Targeted histone deacetylase inhibition for cancer therapy. Curr. Cancer Drug Targets 4: 205-218.

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