Anti-FVIIa | Coagulation factor VIIa (500 µg)

Product no: AS00 001-500

AS00 001-500  |  Clonality: Polyclonal  |  Host: Rabbit  |  Reactivity: Human 

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  • Product Info
  • Immunogen:

    Recombinant human Factor VIIa (NovoSeven ®, Novo Nordisk  A/S Denmark)

    Host: Rabbit
    Clonality: Polyclonal
    Purity: Immunogen affinity purified IgG in PBS pH 7.4.
    Format: Lyophilized
    Quantity: 500 µg
    Reconstitution: For reconstitution add 500 µl of sterile water
    Storage: Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them, to avoid any losses that might occur from material adhering to the cap or sides of the tube.
    Tested applications: Prothrombin assay with human plasma (PT), thrombin generation assay, inhibition assay with Factor VIIa with TF and a chromogenic substrate, inDirect ELISA (I-ELISA)
    Recommended dilution: 1 : 15 000 (I-ELISA)
    Expected | apparent MW:

    52 kDa

  • Reactivity
  • Confirmed reactivity: Human
    Predicted reactivity: Primates
    Not reactive in: No confirmed exceptions from predicted reactivity are currently known
  • Additional Information
  • Additional information: No significant difference in binding to Factor VII and Factor VIIa.

    Antibody is purified to total IgG fraction, followed by purification on specific FVIIa column.
  • Background
  • Background:

    Factor VIIa (FVIIa) is a key serine protease involved in the initiation of the coagulation cascade. FVIIa requires tissue factor (TF), a membrane bound protein, as an essential cofactor for maximal activity towards its biological substrates Factor X, Factor IX and Factor VII (FVII).

  • Product Citations
  • Selected references: Lopez-Vilchez et al. (2009). Traffic of rFVIIa through Endothelial Cells and Redistribution into Subendothelium: Implications for a Prolonged Hemostatic Effect. Journal of Coagulation Disorders, October 1: (1). (immunolocalization)
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